DISCOVERIES (ISSN 2359-7232), 2014, July-September

CITATION: 

Zhvania MG, Bikashvili TZ, Japaridze NJ, Lazrishvili II, Ksovreli M. White noise and neuronal porosome complex: transmission electron microscopic study. Discoveries 2014, Jul-Sep; 2(3): e25. DOI: 10.15190/d.2014.17 

Submitted: June 02, 2014; Revised: August 12, 2014; Accepted: August 13, 2014; Published: August 19, 2014; 

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White noise and neuronal porosome complex: transmission electron microscopic study

Mzia G. Zhvania (1,2,*), Tamar Z. Bikashvili (2), Nadezhda J. Japaridze (2,3), Ilia I. Lazrishvili (2), Mariam Ksovreli (1)

(1) Institute of Chemical Biology, Ilia State University, 3/5 K. Cholokashvili Avenue, 0162 Tbilisi, Georgia;

(2) I. Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 0160 Tbilisi, Georgia;

(3) New Vision University, 1a, Mikeladze Street, 0159 Tbilisi, Georgia

*Correspondence to: Mzia Zhvania, PhD, ScD, Professor of Neuroanatomy, Institute of Chemical Biology, Ilia State University, 3/5 K. Cholokashvili Avenue, 0162, Tbilisi, Georgia; Head, Laboratory of Neuron Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 0162 Tbilisi, Georgia; E-mail: mzia_zhvania@iliauni.edu.ge

Abstract

In the present electron microscopic study the effect of continuous white noise on the morphology of synapses and neuronal porosome complex (the neurotransmitter-release or secretory machinery) in two subcortical auditory brain regions - colliculus inferior and medial geniculate body in cat, were investigated. Several morphological alterations in some synapses were detected in both subcortical areas. These alterations mainly indicate to the decrease of functional activity of synapses. Rarely important pathological modifications in pre- and post-synaptic regions were detected. In addition to descriptive studies, the morphometric analysis of porosome diameter and depth was performed in colliculus inferior and medial geniculate body. The results revealed that while white noise has no effect on the porosome diameter and depth in colliculus inferior, it provokes significant alterations in the morphology of porosome complex in medial geniculate body. In particular, the significant increase of porosome depth in this nucleus may reflect the alteration in neurotransmission.

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References:

1. Cho SJ, Jeftinija K, Glavaski A, Jena BP, Anderson LL. Structure and dynamics of the fusion pores in live GH secreting cells revealed using atomic force microscopy. Endocrinology, 2002; 143: 1144-1148.

2. Cho SJ, Quinn AS, Stromer MH, Dash S, Cho J, Taatjes DJ at al. Structure and dynamics of the fusion pore in live cells. Cell Biol Int. 2002; 26: 35-42.

3. Cho W-J, Jeremic A, Rognlien KT, Zhvania MG, Lazrishvili IL, Tamar B et al. Structure, isolation, composition and reconstitution of the neuronal fusion pore. Cell Biol Int. 2004; 699-708.

4. Drescher DG, Cho W-J, Drescher M. Identification of the porosome complex in the hair cell. Cell Biol Int Rep. 2011; 18: 31-34.

5. Japaridze NJ, Okuneva VG, Qsovreli MG, Surmava AG, Lordkipanidze TG, Kiladze M, Zhvania MG. Hypokinetic stress and neuronal porosome complex in the rat brain: the electron microscopic study. Micron, 2012; 43, 9: 948-963.

6. Schneider SW, Sritharan KC, Geibel JP, Oberleithner H, Jena BP. Surface dynamics in living acinar cells imaged by atomic force microscopy: identification of plasma membrane structures. Proc Natl Acad Sci USA. 1997; 94: 316-321.

7. Siskou L, Rostaining P, Lechaire JP, Boudlier T, Ohtsuka T, Fejtova A et al. Three-dimensional architecture of presynaptic terminal cytomatrix. J Neurosci. 2007; 27: 6868-6877.

8. Cho W-J, Ren G, Lee J-S, Jeftinija K, Jena B. Nanoscale three-dimensional contour map of protein assembly: within the astrocyte porosome complex. Cell Biol Int. 2009; 33: 224-229.

9. Cho W-J, Lee J-S, Jena B. Conformation states of the neuronal Porosome complex. Cell Biol. Int. 2010; 34, 11: 1129-1132

10. Kovari LC, Brunzelle JS, Lewis KT, Cho W-J, Lee J-S, Taatjes DT, Jena P. X-ray solution structure of the native neuronal porosome-synaptoc vesicle complex: Implication in neurontrasmitter release. Micron 2014; 56: 37-43.

11. Lee J-S. Cho W-J, Jeftiniya K, Jeftinija S, Jena B. Porosome in astrocytes. J. Cell Mol. Med. 2009; 13: 365-372.

12. Okuneva VG. Japarodze NJ. Kotaria NT, Zhvania MG. Neuronal porosome in the rat and cat brain, Tsitologiya, 2012; 54: 210-215.

13. Okuneva VC, Japaridze NJ, Kotaria NT, Zhvania MG. Neuronal porosome in the rat and cat brain. J Cell and Tissue Biology, 2012; 6, 1: 69-72.

14. Zhvania MG, Japaridze NJ, Qsovreli MG, Okuneva VG, Surmava AG, Lordkipanidze TG. The Neuronal porosome complex in mammalian brain: a study using electron microscope. NanoCellBiology. Multimodal Imaging in Biology and Medicine. Edited by Bhanu P Jena and Douglas J Taajes. 2014. Pan Stanford Publishing Pre. Ltd.

15. Zhvania MG, Japaridze NJ, Ksovreli M. Effect of different forms of hypokiensia on the ultrastructure of limbic, extrapyramidal and neocortical areas of the rat brain: electron microscopic study. Proceedings of Physics, Springer International Publishing Switzerland, 2014, 15; 21-16.

16. Eggermont JJ. The role of sound in adult and developmental auditory cortical plasticity. Ear Hear. 2008; 6 : 819-829.

17. Zhu X, Wang F, Hu H, Sun X, Kilgard MP, Merzenich MM et al. Environmental acoustic enrichment promotes recovery from developmentally degraded auditory cortical processing. J Neurosci. 2014; 34, 16 : 5406-5415.

18. Soderlind GBW, Sikstrom S, Sonuga-Narke EJ. The effects of background white noise on memory performance in inattentive school children. Behav Brain Funct.2010; 6, 55. doi: 10.1186/1744-9081-6-55.

19. Cheng L, Wang SH, Chen QC, Liao XM. Moderate noise induced cognition impairment of mice and its underlying mechanisms. Physiol Behav. 2011; 104, 5: 981-988.

20. Wang X, Jena PH, Wu FJ, Chen QC. Preceding weak noise sharpens the frequency tuning and elevates the response threshold of the mouse inferior collicular neurons through GABAergic inhibition. Brain Res. 2007; 1167: 80-91.

21. Cui B, Wu M, She X, Liu H. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain Res. 2012; 1427: 35-43.

22. Cui B, Wu MQ, Zhu LX, She XJ, Ma Q, Liu HT. Effect if chronic noise exposure on expression of N-methy;-D-aspartic acid receptor 2B and Tau phosphorylation in hippocampus of rats. Biomed Environ Sci. 2013; 26, 3: 163-168.

23. Rausch VH, Bauch EM, Bunzeck N. White noise improves learning by modulating activity in dopamineric midbrain regions and right superior temporal sulcus. J Cogn Neurosci. 2014; 7: 1469-1480.

24. Basta D, Tzchentke B, Emst A. Noise-induced cell death in the mouse medial geniculate body and primary auditory cortex. Neurosci Lett. 2005; 381, 2: 199-204;

25. Groschel M, Gotze R, Ernst A, Basta D. Differential impact of temporary and permanent noise-induced hearing loss on neuronal cell density in the mouse central auditory pathway. Neurotrauma 2010; 27, 8; 1499-1507.

26. Coorde A, Groschel M, Ernst A, Basta D. Apoptotic cascades in the central auditory pathway after noise exposure. J Neurotrauma 2012; 29, 6: 1249-1254.

27. Cui B, Zhu L, She X, Wu M, Ma Q, Wang T et al. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocamous and prefrontal cortex. Exp Neurol. 2012; 238, 2: 122-129.

28. Pienkowski M, Eggermont JI. Reversible long-term changes in auditory processing in mature auditory cortex in the absence of hearing loss induced by passive, moderate-level sound exposure. Ear Hear. 20120; 33, 3: 305-314.

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