Discoveries Interview: Professor George A. Calin on non-coding RNAs
DISCOVERIES (ISSN 2359-7232), 2014, October-December
CITATION:
Discoveries Interview: Professor George A. Calin on non-coding RNAs. Discoveries 2014, Oct-Dec; 2(4): e32. DOI: 10.15190/d.2014.24;
Submitted: October 31, 2014; Accepted: November 6, 2014; Published: November 7, 2014;
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Discoveries Interview: Professor George A. Calin on non-coding RNAs
Professor George A. Calin, MD, PhD, received his MD and PhD degrees from “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania. Professor Calin continued his cancer genomics training in Doctor Massimo Negrini’s laboratory at University of Ferrara, in Italy. In 2000 he became a postdoctoral fellow at Kimmel Cancer Center in Philadelphia, PA, in Carlo Croce’s laboratory. He is presently a Professor in Experimental Therapeutics, Division of Cancer Medicine, and Co-Director of the Center for RNA Interference and Non-Coding RNAs, at MD Anderson Cancer Center, Houston, TX, USA.
Professor George Calin authored more than 259 scientific articles and received several awards and fellowships, including the 2013 Celgene Award for Clinical Research in Hematology, from Celgene.
Together with Professor Carlo M. Croce and other collaborators, Prof. George Calin pioneered the idea that small non-coding RNAs – microRNA genes (miRNAs) are involved in human tumorigenesis (Calin et al., Proc Natl Acad Sci USA, 2002). He also proved that another family of ncRNAs, named ultraconserved genes (UCGs), are involved in human cancers and directly interact with miRNAs (Calin et al., Cancer Cell, 2007). Professor Calin’s work is now focused on the translation of these discoveries to better diagnosis and treat cancer patients.
Access full text of the manuscript here: See full text (pdf)
References
1. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 2002 Nov 26; 99(24): 15524-9.
View article (DOI) PubMed2. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007 Sep;12(3):215-29.
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