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Discoveries Interview: Prof. Garth L. Nicolson on cellular membrane structure

DISCOVERIES (ISSN 2359-7232), 2013, October-December

CITATION:

Discoveries Interview: Prof. Garth L. Nicolson on cellular membrane structure. Discoveries 2013, Oct-Dec; 1(1): e2. DOI: 10.15190/d.2013.2;

Submitted: December 23, 2013; Published after revision: December 31, 2013

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Discoveries Interview: Prof. Garth L. Nicolson on cellular membrane structure

Over 40 years after the Singer – Nicolson fluid-mosaic model was launched, what have we learned ?

Professor Emeritus Garth L. Nicolson is the President, Chief Scientific Officer and Research Professor at the Institute for Molecular Medicine in Huntington Beach, CA, USA. He is also a Conjoint Professor at the University of Newcastle, (Australia).

He was formally the David Bruton Jr. Chair in Cancer Research and Professor and Chairman of the Department of Tumor Biology at the University of Texas M. D. Anderson Cancer Center in Houston, and he was Professor of Internal Medicine and Professor of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston. He was also Professor of Comparative Pathology at Texas A & M University.

Professor Nicolson has published over 600 medical and scientific papers, including editing 19 books, and he has served on the Editorial Boards of 30 medical and scientific journals and was a Senior Editor of four of these. Professor Nicolson has won many awards, such as the Burroughs Wellcome Medal of the Royal Society of Medicine (United Kingdom), Stephen Paget Award of the Metastasis Research Society, the US National Cancer Institute Outstanding Investigator Award, and the Innovative Medicine Award of Canada.

He is also a Colonel (Honorary) of the US Army Special Forces and a US Navy SEAL (Honorary) for his work on Armed Forces and veterans’ illnesses.

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References

1.Resovi A, Pinessi D, Chiorino G and Taraboletti G. Current understanding of the thrombospondin-1 interactome. Matrix Biol. 2014; in press.
2.Lawler J. Thrombospondin 1. UCSD Nature Molecule Pages 2010. doi: 10.1038/mp.a002276.01.
3.Lawler JW, Slayter HS and Coligan JE. Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem. 1978; 253:8609-8616.
4.Schultz-Cherry S and Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol. 1993; 122:923-932.
5.Lawler J and Hynes RO. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol. 1986; 103:1635-1648.
6.Dameron KM, Volpert OV, Tainsky MA and Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994;265:1582-1584.

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