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DISCOVERIES - 2014, No. 3 (JULY-SEPTEMBER); Special issue on "Cell Secretion and Membrane Fusion"


2014, No. 3 (July-September)

Manuscripts for this issue are now published.
Original Article Featured on the Cover:

Zhvania MG, Bikashvili TZ, Japaridze NJ, Lazrishvili II, Ksovreli M. White noise and neuronal porosome complex: transmission electron microscopic study. Discoveries 2014, Jul-Sep; 2(3): e25. DOI: 10.15190/d.2014.17 ;
In the picture - a cup-shaped neuronal porosome


Prof. Mircea Leabu, PhD
Head of Cell Biology Laboratory,"Victor Babes" National Institute and Associate Professor,"CAROL DAVILA" University of Medicine and Pharmacy, Bucharest, Romania. ( read more 

Prof. Garth L. Nicolson, PhD
Professor Emeritus, President and Founder of the Institute for Molecular Medicine, CA, USA, formally David Bruton Jr. Chair in Cancer Research and Chairman of the Department of Tumor Biology at University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA. ( read more



Cell secretion and membrane fusion: highly significant phenomena in the life of a cell

Mircea Leabu*, Garth L. Nicolson**
Read FULL ARTICLE (pdf)  Citation & References  DOI: 10.15190/d.2014.22  Citations: 0 
Corresp. authors' affiliation:
* Head of Cell Biology Laboratory, "Victor Babes" National Institute and Associate Professor, "CAROL DAVILA" University of Medicine and Pharmacy, Bucharest, Romania
** Professor Emeritus, President and Founder of the Institute for Molecular Medicine, CA, USA, formally David Bruton Jr. Chair in Cancer Research and Chairman of the Department of Tumor Biology at University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA

Discoveries Interview: Professor Bhanu P. Jena on the discovery of the porosome, the universal machinery for cellular secretion

Professor Bhanu P. Jena received his Ph.D. degree in Endocrinology, and the Research Excellence Award from Iowa State University in 1988. Following postdoctoral training at Iowa State and Yale Universities (1989-1994), Prof. Jena joined Yale University, as an Assistant Professor, and in 2000, moved to the Department of Physiology, at Wayne State University School of Medicine, as Professor, and Founder-Director of the Institute of NanoBioScience. In 2004, he was conferred the distinction of George E. Palade University Professor and Distinguished Professor. Prof. Jena has received numerous awards and honors for his discoveries, Read More

Insights into the Nanobiology of Growth Hormone Secretion

Lloyd L. Anderson*
Read FULL ARTICLE (pdf)  Abstract, Citation & References  DOI: 10.15190/d.2014.14  Citations: 1  
Corresp. author's affiliation: *Emeritus Professor of Animal Science, Charless F. Curtiss Distinguished Professor in Agriculture and Life Sciences, Iowa State University, Ames, IA, USA

White noise and neuronal porosome complex: transmission electron microscopic study

Mzia G. Zhvania*, Tamar Z. Bikashvili, Nadezhda J. Japaridze, Ilia I. Lazrishvili, Mariam Ksovreli
Read FULL ARTICLE (pdf)  Abstract, Citation & References  DOI: 10.15190/d.2014.17  Citations: 3
Corresp. author's affiliation: *Head, Laboratory of Neuron Ultrastructure and Nanoarchitecture, I. Beritashvili Center of Experimental Biomedicine & Ilia State University, Tbilisi, Georgia. 


REVIEW Articles

Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It

Ilan Hammel*, Isaac Meilijson**
Read FULL ARTICLE (pdf)  Suppl. Material (pdf)  Abstract, Citation & References  DOI: 10.15190/d.2014.13  Citations: 4
Corresp. author's affiliation:  *Head of the Faculty Graduate School, Department of Pathology, Tel Aviv University & **Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel

Porosome in the Exocrine Pancreas: A Detailed EM Study

Constantin Craciun*
Read FULL ARTICLE (pdf)  Suppl. Material (pdf)  Abstract, Citation & References  DOI: 10.15190/d.2014.15  Citations: 1
Corresp. author's affiliation: *Director, Center of Electron Microscopy, Babes-Bolyai University, Cluj-Napoca, Romania 

Porosome in Cystic Fibrosis

Bhanu P. Jena*
Read FULL ARTICLE (pdf)  Abstract, Citation & References  DOI: 10.15190/d.2014.24  Citations: 1
Corresp. author's affiliation: *Bhanu P. Jena, Ph.D., D.Sc., (dr. h.c. mult.), George E. Palade University Professor, Distinguished Professor, Department of Physiology, Wayne State University School of Medicine; Director of the NanoBioScience Institute, Detroit, MI, USA 

Porosome: a membrane microdomain acting as the universal secretory portal in exocytosis

Mircea Leabu*, Cristina Mariana Niculite
Read FULL ARTICLE (pdf)  Abstract, Citation & References  DOI: 10.15190/d.2014.21  Citations: 4
Corresp. author's affiliation: *Head of Cell Biology Laboratory, "Victor Babes" National Institute, and Associate Professor, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania 




Exosomes: Emerging Players of Intercellular Communication in Tumor Microenvironment

Shrankhla Maheshwari, Anup Kumar Singh, Rakesh Kumar Arya, Deepti Pandey, Akhilesh Singh, Dipak Datta*
Read FULL ARTICLE (pdf)  Abstract, Citation & References  DOI: 10.15190/d.2014.18  Citations: 6

Corresp. author's affiliation: *CSIR-Central Drug Research Institute (CDRI), Lucknow, India & Academy of Scientific and Innovative Research, New Delhi, India

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  • 2014, September | Special Issue

    DISCOVERIES just publish the SPECIAL ISSUE entitled "CELL SECRETION & MEMBRANE FUSION" in September 2014. Initially scheduled for publication between October 2014-March 2015, this issue was successfully published earlier than scheduled. 

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