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Myosin activators in heart failure

DISCOVERIES (ISSN 2359-7232), 2014, Oct-Dec

Andrei S, Iorgoveanu C. New perspective in heart failure management: could myosin activators be the answer? Discoveries 2014, Oct-Dec; 2(4): e33. DOI: 10.15190/d.2014.25

Submitted: December 08th, 2014; Revised: December 22nd, 2014; AcceptedDecember 30th, 2014Published: December 31st, 2014;

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New perspective in heart failure management: could myosin activators be the answer?

(1,*), (2)

(1) “CNHO des Quinze-Vingts, Service de Médecine Interne, Paris, France; 
(2) CC Iliescu Institute of Cardiovascular Diseases, Cardiology, Bucharest, Romania; 

*Correspondence toStefan Andrei, MD, CNHO des Quinze-Vingts, Service de Médecine Interne, 28, Rue de Charenton, 75 571 Paris Cedex 12, France; Email: stefanmandrei@gmail.com;


Heart failure is a worldwide leading cause of hospital admissions. There is a critical need for new methods of management in acute heart failure.  The current drug panel available in the treatment of hemodinamically unstable patients is not only limited, but it is also associated with deleterious side effects. Discoveries in the heart failure field seemed to lack an adequate answer and a change in paradigm may be necessary. The cardiac myosin activator omecamtiv mecarbil is a new therapeutic approach that improves the myocardial contractility through an innovative mechanism, avoiding the harmful effects of currently used inotropic agents.  Several studies provided us with promising results, but further scientific proofs are needed.

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