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Inflammation between defense and disease

DISCOVERIES (ISSN 2359-7232), 2015, January-March


Liehn EA, Cabrera-Fuentes HA. Inflammation between defense and disease: impact on tissue repair and chronic sickness. Discoveries 2015, Jan-Mar, 3(1): e42. DOI: 10.15190/d.2015.34 

Submitted: March 29, 2015; Revised: March 31, 2015; Accepted: March 31, 2015; Published: March 31, 2015; 

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Inflammation between defense and disease: impact on tissue repair and chronic sickness

Elisa A. Liehn (1,*), Hector A. Cabrera-Fuentes (2,3,4,*)

(1) Institute of Molecular Cardiovascular Research, RWTA Aachen, Aachen, Germany

(2) Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany

(3) Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore

(4) National Heart Research Institute Singapore, National Heart Centre Singapore

*Correspondence to

Elisa A. Liehn, MD, PhD, Institute of Molecular Cardiovascular Research, RWTA Aachen, Aachen, Germany, Pauwelsstr. 30, D-52074 Aachen, Germany; E-mail: eliehn@ukaachen.de;

Hector A. Cabrera-Fuentes, Ph.D, Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany, Friedrichstr. 24, D-35392 Giessen, Germany; E-mail: Hector.A.Cabrera-Fuentes@biochemie.med.uni-giessen.de

Access full text of the manuscript here: 

Funding and Acknowledgements:

This work was supported by IZKF founding RWTH Aachen to Dr. Elisa A Liehn’s research group. This work was also supported in part by a Startup Grant from Excellence Cluster Cardio-Pulmonary System and Peter und Traudl Engelhorn-Stiftung to Dr. Cabrera-Fuentes.



1. Frangogiannis NG. Targeting the inflammatory response in healing myocardial infarcts. Curr Med Chem 2006; 13:1877-93.

View article (DOI)  PubMed  Google Scholar

2. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immun 2005;6:1191-7.

View article (DOI)  PubMed  Google Scholar

3. Sato Y, Ohshima T, Kondo T. Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing. Biochem Biophys Res Comm 1999; 265:194-9. 

View article (DOI)  PubMed  Google Scholar

4. Greenhalgh DG. The role of apoptosis in wound healing. Internat J Biochem Cell Biol 1998;30:1019-30.

View article (DOI)  PubMed  Google Scholar

5. Serhan CN. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodont 2008; 79:1520-6.

View article (DOI)  PubMed  Google Scholar

6. Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol 2010; 48:504-11.

View article (DOI)  PubMed  Google Scholar

7. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrin Met 2004; 89:2548-56.

View article (DOI)  PubMed  Google Scholar

8. Esposito K, Nappo F, Marfella R et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002; 106:2067-72.

View article (DOI)  PubMed  Google Scholar

9. van Dijk SJ, Feskens EJ, Bos MB et al. A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome. Am J Clin Nutr 2009; 90:1656-64.

View article (DOI)  PubMed  Google Scholar

10. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006;116:1793-801.

View article (DOI)  PubMed  Google Scholar

11. Toth MJ, Matthews DE, Tracy RP, Previs MJ. Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am J Endocrin Met 2005; 288:E883-91. 

View article (DOI)  PubMed  Google Scholar

12. Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. Jama 1999; 281:1722-7.

View article (DOI)  PubMed  Google Scholar

13. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454:436-44.

View article (DOI)  PubMed  Google Scholar

14. Balkwill FR, Mantovani A. Cancer-related inflammation: common themes and therapeutic opportunities. Sem Cancer Biol 2012; 22:33-40.

View article (DOI)  PubMed  Google Scholar

15. Del Prete A, Allavena P, Santoro G, Fumarulo R, Corsi MM, Mantovani A. Molecular pathways in cancer-related inflammation. Biochem Med 2011; 21:264-75.

View article (DOI)  PubMed  Google Scholar

16. Locatelli M, Ferrero S, Martinelli Boneschi F et al. The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas. J Neuroimmun 2013; 260:99-106.

View article (DOI)  PubMed  Google Scholar

17. Liehn EA, Zernecke A, Postea O, Weber C. Chemokines: inflammatory mediators of atherosclerosis. Arch Physiol Biochem 2006; 112:229-38.

View article (DOI)  PubMed  Google Scholar

18. Liehn EA, Postea O, Curaj A, Marx N. Repair after myocardial infarction, between fantasy and reality: the role of chemokines. J Am Coll Cardiol 2011; 58:2357-62.

View article (DOI)  PubMed  Google Scholar

19. Roberts R, DeMello V, Sobel BE. Deleterious effects of methylprednisolone in patients with myocardial infarction. Circulation 1976;53:I204-6.

View article (DOI)  PubMed  Google Scholar

20. Berk M, Williams LJ, Jacka FN et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine 2013;11:200.

View article (DOI)  PubMed  Google Scholar

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