Existing users Log In New users Sign up

Inflammation between defense and disease

DISCOVERIES (ISSN 2359-7232), 2015, January-March


Liehn EA, Cabrera-Fuentes HA. Inflammation between defense and disease: impact on tissue repair and chronic sickness. Discoveries 2015, Jan-Mar, 3(1): e42. DOI: 10.15190/d.2015.34 

Submitted: March 29, 2015; Revised: March 31, 2015; Accepted: March 31, 2015; Published: March 31, 2015; 

GO BACK to 2015, January-March issue 

Inflammation between defense and disease: impact on tissue repair and chronic sickness

Elisa A. Liehn (1,*), Hector A. Cabrera-Fuentes (2,3,4,*)

(1) Institute of Molecular Cardiovascular Research, RWTA Aachen, Aachen, Germany

(2) Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany

(3) Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore

(4) National Heart Research Institute Singapore, National Heart Centre Singapore

*Correspondence to

Elisa A. Liehn, MD, PhD, Institute of Molecular Cardiovascular Research, RWTA Aachen, Aachen, Germany, Pauwelsstr. 30, D-52074 Aachen, Germany; E-mail: eliehn@ukaachen.de;

Hector A. Cabrera-Fuentes, Ph.D, Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany, Friedrichstr. 24, D-35392 Giessen, Germany; E-mail: Hector.A.Cabrera-Fuentes@biochemie.med.uni-giessen.de

Access full text of the manuscript here: 

Funding and Acknowledgements:

This work was supported by IZKF founding RWTH Aachen to Dr. Elisa A Liehn’s research group. This work was also supported in part by a Startup Grant from Excellence Cluster Cardio-Pulmonary System and Peter und Traudl Engelhorn-Stiftung to Dr. Cabrera-Fuentes.



1. Frangogiannis NG. Targeting the inflammatory response in healing myocardial infarcts. Curr Med Chem 2006; 13:1877-93.

View article (DOI)  PubMed  Google Scholar

2. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immun 2005;6:1191-7.

View article (DOI)  PubMed  Google Scholar

3. Sato Y, Ohshima T, Kondo T. Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing. Biochem Biophys Res Comm 1999; 265:194-9. 

View article (DOI)  PubMed  Google Scholar

4. Greenhalgh DG. The role of apoptosis in wound healing. Internat J Biochem Cell Biol 1998;30:1019-30.

View article (DOI)  PubMed  Google Scholar

5. Serhan CN. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodont 2008; 79:1520-6.

View article (DOI)  PubMed  Google Scholar

6. Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol 2010; 48:504-11.

View article (DOI)  PubMed  Google Scholar

7. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrin Met 2004; 89:2548-56.

View article (DOI)  PubMed  Google Scholar

8. Esposito K, Nappo F, Marfella R et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002; 106:2067-72.

View article (DOI)  PubMed  Google Scholar

9. van Dijk SJ, Feskens EJ, Bos MB et al. A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome. Am J Clin Nutr 2009; 90:1656-64.

View article (DOI)  PubMed  Google Scholar

10. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006;116:1793-801.

View article (DOI)  PubMed  Google Scholar

11. Toth MJ, Matthews DE, Tracy RP, Previs MJ. Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am J Endocrin Met 2005; 288:E883-91. 

View article (DOI)  PubMed  Google Scholar

12. Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. Jama 1999; 281:1722-7.

View article (DOI)  PubMed  Google Scholar

13. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454:436-44.

View article (DOI)  PubMed  Google Scholar

14. Balkwill FR, Mantovani A. Cancer-related inflammation: common themes and therapeutic opportunities. Sem Cancer Biol 2012; 22:33-40.

View article (DOI)  PubMed  Google Scholar

15. Del Prete A, Allavena P, Santoro G, Fumarulo R, Corsi MM, Mantovani A. Molecular pathways in cancer-related inflammation. Biochem Med 2011; 21:264-75.

View article (DOI)  PubMed  Google Scholar

16. Locatelli M, Ferrero S, Martinelli Boneschi F et al. The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas. J Neuroimmun 2013; 260:99-106.

View article (DOI)  PubMed  Google Scholar

17. Liehn EA, Zernecke A, Postea O, Weber C. Chemokines: inflammatory mediators of atherosclerosis. Arch Physiol Biochem 2006; 112:229-38.

View article (DOI)  PubMed  Google Scholar

18. Liehn EA, Postea O, Curaj A, Marx N. Repair after myocardial infarction, between fantasy and reality: the role of chemokines. J Am Coll Cardiol 2011; 58:2357-62.

View article (DOI)  PubMed  Google Scholar

19. Roberts R, DeMello V, Sobel BE. Deleterious effects of methylprednisolone in patients with myocardial infarction. Circulation 1976;53:I204-6.

View article (DOI)  PubMed  Google Scholar

20. Berk M, Williams LJ, Jacka FN et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine 2013;11:200.

View article (DOI)  PubMed  Google Scholar

GO BACK to the 2015, January-March issue

Email Email us at info@discoveriesjournals.org if you have any questions.

News & Events Latest news from Discoveries

  • 2019, September | Indexed by PMC

    Discoveries is now indexed by PubMedCentral and Pubmed. The agreement with US National Library of Medicine was signed on September 10th, 2019. Our next step is ISI indexing.

  • 2019, August | PubMed inclusion News!

    We are happy to let you know that Discoveries successfuly passed the last step (Technical Review) required for PubMedCentral and PubMed inclusion!

  • 2019, July | PubMed inclusion News!

    We are happy to receive positive comments from PMC/NLM-NIH regarding Discoveries' last step (Technical Review) required for PubMedCentral and PubMed inclusion. We will let you know once whole indexing process is completed. 

  • 2019| Sharing and Distribution!

    All articles published in Discoveries are Open Access articles distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 2018-2019 | For Authors!

    From now on and for at least 1 year, we will only accept articles from authors that are NOT members of Discoveries' Editorial Board. All articles submitted by our editors will be immediately rejected until further notice (one accepted article was already rejected). 

  • 2018 | PubMed inclusion News!

    Discoveries successfully passed the Scientific Quality Review by NLM-NIH for PubMedCentral and PubMed indexing. This is the first and the most important step towards PubMedCentral and PubMed indexing! The second (last) step is the Technical Review.

  • 2016, April | Faster Peer-Review

    Starting on April 13th 2016, all articles selected for a peer-review will receive the post peer-review decision within ~10 days. The initial pre-screening time will remain the same (48h from the submission of the manuscript). This decision will significantly accelerate the publication, with no effect on the quality of the peer-review process.

  • 2016, February | Manuscript submission

    Discoveries is commited to excellence, quality and high editorial standards. We are receiving an increasing number of manuscripts for which the identity of the authors/corresponding author can't be verified. Please NOTE that ALL these articles were and will be immediately REJECTED. Indicating an institutional email address is the easiest way to overcome this problem! Moreover, we do not accept any pressure on our editorial board to accept a manuscript. This results in a prompt rejection of the article.

    Editorial Policies
  • 2016, January | Main Objective

    After reaching all proposed milestones until now (including being indexed by Google Scholar in 2014), Discoveries' next Aim is PubMed indexing of all its articles (already published and upcoming). There will be no charge for the submission or publication of articles before Discoveries is indexed.

  • 2015, August | Discoveries - on PubMed

    We are happy to announce that our first Discoveries articles were included in PMC and PubMed. More articles (submitted by NIH funded authors) are now processed for being included.

    Discoveries articles now on PubMed
  • 2015, April | Special Issue

    DISCOVERIES published the SPECIAL ISSUE entitled "INFLAMMATION BETWEEN DEFENSE AND DISEASE: Impact on Tissue Repair and Chronic Sickness".

    Special Issue on "Inflammation"
  • 2015 | Ischemia Collection

    DISCOVERIES launched a call for papers for a Collection of Articles with focus on "ISCHEMIA". If you are interested to submit a manuscript, please contact us at info@discoveriesjournals.org

  • 2014, September | Special Issue

    DISCOVERIES just publish the SPECIAL ISSUE entitled "CELL SECRETION & MEMBRANE FUSION" in September 2014. Initially scheduled for publication between October 2014-March 2015, this issue was successfully published earlier than scheduled. 

    Special Issue
  • 2014, April | Indexed by Google Scholar

    All our published articles are now indexed by Google Scholar! First citations to Discoveries articles are included! Search for the article's title (recommended) or the authors:

    Google Scholar Search
  • 2014 | DISCOVERIES

    DOIs (Digital Object Identifiers) are now assigned to all our published manuscripts in Discoveries. DOI uniquely identifies an article and is provided by CrossRef.

  • 2013, July | Manuscript Submission

    Submit your manuscript FREE, FAST and EASY ! (in less than 1 minute)! There are NO fees for the manuscript submission or publishing of the accepted manuscripts.
    read more

  • 2013, July | DISCOVERIES

    We are now ACCEPTING MANUSCRIPTS for publishing in DISCOVERIES. We aim publishing a small number of high impact experimental articles & reviews (around 40/year) to maintain a high impact factor. Domains of interest: all areas related to Medicine, Biology and Chemistry ...

    read more
Member Login
Free Registration Click here to sign up
Copyright © 2013 Applied Systems. All Rights Reserved.