Existing users Log In New users Sign up


Inflammation and Cerebrovascular Disorders in Aged Subjects

DISCOVERIES (ISSN 2359-7232), 2015, January-March issue

CITATION: 

Uzoni A, Ciobanu O, Sandu RE, Buga AM, Popa-Wagner ALife style, Perfusion deficits and Co-morbidities Precipitate Inflammation and Cerebrovascular Disorders in Aged Subjects. Discoveries 2015, Jan-Mar; 3(1): e39. DOI: 10.15190/d.2015.31

 Submitted: March 09, 2015; RevisedMarch 27, 2015AcceptedMarch 27, 2015Published: March 31, 2015;

 GO BACK to DISCOVERIES

Life style, Perfusion deficits and Co-morbidities Precipitate Inflammation and Cerebrovascular Disorders in Aged Subjects

Adriana Uzoni (1,4), Ovidiu Ciobanu (2,3), Raluca Elena Sandu (2), Ana Maria Buga (1,2), Aurel Popa-Wagner (1,2,*)

(1) Department of Psychiatry, University of Medicine Rostock, Germany

(2) Center of Clinical and Experimental Research, University of Medicine and Pharmacy, Craiova, Romania

(3) Department of Psychiatry, University Medicine of Saarland, Homburg/Saar, Germany 

(4) Biochemistry Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania

*Correspondence to: Aurel Popa-Wagner, MD, PhD, Department of Psychiatry, University of Medicine Rostock, Gehlsheimerstr. 20, 18147 Rostock, Germany. Phone: +49-381-494-9686; Fax: +49-381-494-9639; E-mail: aurel.popa-wagner@med.uni-rostock.de

Abstract

Cerebrovascular diseases represent 2nd leading cause of death worldwide. Understanding how genetic predispositions and their interaction with environmental factors affect cerebrovascular diseases is fundamental for prevention, diagnosis and for the development of safe and efficient therapies. Cerebrovascular diseases have not only a very high mortality rate, but also results in debilitating neurological impairments or permanent disability in survivors associated with huge economic losses. Among the women and men individuals with a low-risk lifestyle (smoking, exercising daily, consuming a prudent diet including moderate alcohol and having a healthy weight during mid-life) had a significantly lower risk of stroke than individuals without a low-risk lifestyle. Current review focuses on determining the relationship between diet, as an important component of ‘life style’, aging and cerebrovascular diseases.This review may help to unravel biological mechanisms linking lifestyle, diet-induced, metabolic inflammation, aging and cerebral hypoperfusion to development of cerebrovascular diseases, a prerequisite for development of science-based preventive strategies needed to combat the major public health challenges like obesity and stroke

Access full text of the manuscript here: 

References

1. Olesen J, Gustavsson A, Svensson M, Wittchen HU, Jönsson B. CDBE2010 study group et al. The economic cost of brain disorders in Europe. Eur J Neurol.2012; 19:155-162.

View article (DOI)  PubMed

2. Sivenius J, Torppa J, Tuomilehto J, Immonen-Räihä P, Kaarisalo M, Sarti C et al. Modelling the burden of stroke in Finland until 2030. Int J Stroke 2009; 4: 340-345.

View article (DOI)  PubMed

3. Bonita R, Beaglehole R. Recovery of motor function after stroke. Stroke 1988; 19: 1497-1500.

View article (DOI)  PubMed

4. Burn J, Dennis M, Bamford J, Sandercock P, Wade D, Warlow C. Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project. Stroke 1994;  25: 333-337.

PubMed

5. Appelros P, Nydevik I, Viitanen M. Poor Outcome After First-Ever Stroke. Predictors for Death, Dependency, and Recurrent Stroke Within the First Year. Stroke 2003; 34(1): 122-126.

View article (DOI)  PubMed

6. Donnan GA, Davis SM. Breaking the 3 h barrier for treatment of acute ischaemic stroke. Lancet Neurol. 2008; 7(11): 981-982.

View article (DOI)  PubMed

7. Sarti C, Rastenyte D, Cepaitis Z, Tuomilehto J. International trends in mortality from stroke 1968 to 1994. Stroke 2000; 31(7): 1588-1601.

View article (DOI)  PubMed

8. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA 2002; 288(20): 2569-2578.

View article (DOI)  PubMed

9. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010; 72: 219-246. 

View article (DOI)  PubMed

10. Poulsen P, Ohm Kyvik K, Vaag A, Beck-Nielen H. Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance ± a population-based twin study. Diabetologia 1999; 42: 139-145.

PubMed

11. Cornelis MC, Hu FB. Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges. Annu Rev Nutr. 2012; 32:245-259.

View article (DOI)  PubMed

12. http://www.genome.gov/gwastudies/

13. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015; 518(7538): 197-206.

View article (DOI)  PubMed

14. Shungin D, Winker TW, Croteau- Chonka DC, Ferreira T, Locke AE, Mägi R et al. New genetic loci link adipocity and insulin biology to body fat distribution. Nature 2015; 518(7538): 187-196.

View article (DOI)  PubMed

15. Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IK, Brown IJ et al. Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol. 2010; 63(9): 970-979.

View article (DOI)  PubMed

16. Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010; 42(2): 137-141.

View article (DOI)  PubMed

17. Teslovich TM, Musunuru K, Smith AV,  Edmondson A, Ioannis M. Stylianou IM, Koseki M et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466(7307): 707-713.

View article (DOI)  PubMed

18. Suhre K, Shin SY, Petersen AK,  Mohney RP, Meredith D, Wägele B et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature 2011; 477(7362): 54-60.

View article (DOI)  PubMed

19. Kettunen J, Tukiainen T, Sarin AP, Alonso AO, Tikkanen E, Lyytikäinen LP  et al., Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet. 2012; 44(3): 269-276. 

View article (DOI)  PubMed

20. Olsen TS, Dehlendorff C, Petersen HG, Andersen KK. Body mass index and poststroke mortality. Neuroepidemiology 2008; 30:93-100.

View article (DOI)  PubMed

21. Towfighi A, Ovbiagele B. The impact of body mass index on mortality after stroke. Stroke 2009; 40: 2704-2708.

View article (DOI)  PubMed

22. Vemmos K, Ntaios G, Spengos K, Savvari P, Vemmou A, Pappa T, et al. Association between obesity and mortality after acute first-ever stroke: the obesity-stroke paradox. Stroke 2011; 42: 30-36.

View article (DOI)  PubMed

23. Ovbiagele B, Bath PM, Cotton D, Vinisko R, Diener HC. Obesity and recurrent vascular risk after a recent ischemic stroke. Stroke 2011;42: 3397-3402.

View article (DOI)  PubMed

24. Andersen KK, Olsen TS. The obesity paradox in stroke: lower mortality and lower risk of readmission for recurrent stroke in obese stroke patients. Int J Stroke 2015; 10: 99-104.

PubMed

25. Ryu WS, Lee SH, Kim CK, Yoon BW. Body mass index, initial neurological severity and long-term mortality in ischemic stroke. Cerebrovasc Dis. 2011; 32: 170-176.

View article (DOI)  PubMed

26. Lu Zhao, Wanliang Du. Favorable Functional Recovery in Overweight Ischemic Stroke Survivors: Findings from the China National Stroke Registry. Journal of Stroke and Cerebrovascular Diseases. 2014; 23: e201-e206. 

View article (DOI)  PubMed

27. Burke DT,  Al-Adawi S.  Effect of Body Mass Index on Stroke Rehabilitation. J Stroke Cerebrovasc Dis. 2014; 23(3): e201-206.

View article (DOI)  PubMed

28. Chiquete, E, Cantú-Brito C. Obesity paradox and functional recovery in first-ever acute ischemic stroke survivors: The PREMIER study. Rev Neurol. 2010; 51: 705-713.

PubMed

29. Kalichman L, Rodrigues B, Gurvich D, Israelov Z, Spivak E. Impact of patient’s weight on stroke rehabilitation results. Am J Phys Med Rehabil. 2007;86:650-655.

View article (DOI)  PubMed

30. Razinia T, Saver JL, Liebeskind DS, Ali LK,Buck B, Ovbiagele B. Body mass index and hospital discharge outcomes after ischemic stroke. Arch Neurol 2007;64:388-391.

View article (DOI)  PubMed

31. Tanizaki Y, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Shinohara N et al. Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama study. Stroke 2000; 31: 2616-2622. 

View article (DOI)  PubMed

32. Downes CE, Crack PJ. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol 2010; 160: 1872-1888. 

View article (DOI)  PubMed

33. Ransohoff RM, Cardona AE. The myeloid cells of the central nervous system parenchyma. Nature 2010; 468: 253-62. 

View article (DOI)  PubMed

34. Becker KJ, Kalil AJ, Tanzi P, Zierath DK, Savos AV, Gee JM et al. Autoimmune responses to the brain after stroke are associated with worse outcome. Stroke 2011; 42: 2763-2769. 

View article (DOI)  PubMed

35. Henry C, Huang Y, Wynne AM, Godbout JP. Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both proinflammatory IL-1[beta] and anti-inflammatory IL-10 cytokines. Brain Behav Immun. 2009; 23: 309–317.

View article (DOI)  PubMed

36. Palin K, Cunningham C, Forse P, Perry VH, Platt N. Systemic inflammation switches the inflammatory cytokine profile in CNS wallerian degeneration. Neurobiol Dis. 2009; 30: 19–29.

View article (DOI)  PubMed

37. Bilbo SD, Schwarz JM. Early-life programming of later-life brain and behavior: A critical role for the immune system. Front Behav Neurosci. 2009; 3:14.

View article (DOI)  PubMed

38. Murray C, Sanderson DJ, Barkus C, Deacon RMJ, Rawlins JNP, Bannerman DM et al. Systemic inflammation induces acute working memory deficits in the primed brain: Relevance for delirium. Neurobiol Aging 2010; 33: 603–616.

View article (DOI)  PubMed

39. Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci. 2005; 25: 9275–9284.

View article (DOI)  PubMed

40. Godbout JP, Johnson RW. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Neurol Clin. 2006; 24: 521–538.

PubMed

41. Dilger RN, Johnson RW. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol. 2008; 84: 932–939.

View article (DOI)  PubMed

42. Surtees PG, Wainwright NW, Boekholdt SM, Luben RN, Wareham NJ, Khaw KT. Major depression, C-reactive protein, and incident ischemic heart disease in healthy men and women. Psychosom Med 2008; 70: 850–855.

View article (DOI)  PubMed

43. Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, Perini G et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis. 2009; 24:27–53.

View article (DOI)  PubMed

44. Taylor WD, Aizenstein HJ, Alexopoulos GS. The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry. 2013 Sep;18(9):963-74.

View article (DOI)  PubMed

45. Raison CL, Demetrashvili M, Capuron L, Miller AH. Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs  2005; 19:105–123.

PubMed

46. Ferreira ED, Romanini CV, Mori MA, de Oliveira RM, Milani H. Middle-aged, but not young, rats develop cognitive impairment and cortical neurodegeneration following the four-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion. Eur J Neurosci. 2011; 34(7): 1131-1140.

View article (DOI)  PubMed

47. Walker AK, Kavelaars A, Heijnen CJ, Dantzer R. Neuroinflammation and Comorbidity of Pain and Depression. Pharmacol Rev. 2013; 66: 80-101.

View article (DOI)  PubMed

48. Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 664–675.

View article (DOI)  PubMed

49. Leonard BE. Inflammation, depression and dementia: are they connected? Neurochem Res. 2007; 32: 1749–1756.

View article (DOI)  PubMed

50. Rojo LE, Fernández JA, Maccioni AA, Jimenez JM, Maccioni RB. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch Med Res. 2008; 39: 1–16.

View article (DOI)  PubMed

51. Byers AL, Yaffe K. Depression and risk of developing dementia. Nat Rev Neurol. 2012; 7(6): 323–331.

View article (DOI)  PubMed

52. Reimer MM, McQueen J, Searcy L, Scullion G, Zonta B, Desmazieres A et al. Journal of Neuroscience 2011, 31(49): 18185–18194.

View article (DOI)  PubMed

53. Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Mari T, Hase Y et al. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2012; 123: 381–394.

View article (DOI)  PubMed

54. Lu FP, Lin KP, Kuo HK. Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis.  PLoS One 2009; 4(1):e4144.

View article (DOI)  PubMed

55. Jorm AF. Is depression a risk factor for dementia or cognitive decline? a review.  Gerontology 2000; 46(4):219-227.

View article (DOI)  PubMed

56. Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis.  Arch Gen Psychiatry 2006; 63(5):530-538.

View article (DOI)  PubMed

57. Ali S, Stone MA, Peters JL, Davies MJ, Khunti K. The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis.  Diabet Med 2006; 23(11):1165-1173.

View article (DOI)  PubMed

58. Katon W, Lyles CR, Parker MM, Karter AJ, Hunag ES, Whitmer RA. Association of Depression With Increased Risk of Dementia in Patients With Type 2 Diabetes: the Diabetes and Aging Study. Arch Gen Psychiatry 2012; 69(4):410-417. 

View article (DOI)  PubMed

 

GO BACK to DISCOVERIES 
MEET OUR EDITORIAL BOARD 
SUBMIT A MANUSCRIPT

Email Email us at info@discoveriesjournals.org if you have any questions.

News & Events Latest news from Discoveries

  • 2018 | For Authors!

    PMC highlighted that a high proportion of authors of Discoveries articles are also members of our Editorial Board. As a result, from now on and for at least 1 year, we will only accept articles from authors that are NOT members of Discoveries' Editorial Board. All articles submitted by our members will be immediately rejected until further notice (one accepted article was already rejected). 

  • 2017-2018 | PubMed inclusion News!

    Discoveries successfully passed the Scientific Quality Review by NLM-NIH for PubMedCentral and PubMed indexing. This is the first and the most important step towards PubMedCentral and PubMed indexing! The second (last) step is the Technical Review.

  • April 2016 | Faster Peer-Review

    Starting on April 13th 2016, all articles selected for a peer-review will receive the post peer-review decision within 10 days. The initial pre-screening time will remain the same (48h from the submission of the manuscript). This decision will significantly accelerate the publication, with no effect on the quality of the peer-review process.

  • February 2016 | Manuscript submission

    Discoveries is commited to excellence, quality and high editorial standards. We are receiving an increasing number of manuscripts for which the identity of the authors/corresponding author can't be verified. Please NOTE that ALL these articles were and will be immediately REJECTED. Indicating an institutional email address is the easiest way to overcome this problem! Moreover, we do not accept any pressure on our editorial board to accept a manuscript. This results in a prompt rejection of the article.

    Editorial Policies
  • January 2016 | Main Objective

    After reaching all proposed milestones until now (including being indexed by Google Scholar in 2014), Discoveries' next Aim is PubMed indexing of all its articles (already published and upcoming). There will be no charge for the submission or publication of articles before Discoveries is indexed.

  • August 2015 | Discoveries - on PubMed

    We are happy to announce that our first Discoveries articles were included in PMC and PubMed. More articles (submitted by NIH funded authors) are now processed for being included.

    Discoveries articles now on PubMed
  • April 2015 | Special Issue

    DISCOVERIES published the SPECIAL ISSUE entitled "INFLAMMATION BETWEEN DEFENSE AND DISEASE: Impact on Tissue Repair and Chronic Sickness".

    Special Issue on "Inflammation"
  • 2015 | Ischemia Collection

    DISCOVERIES launched a call for papers for a Collection of Articles with focus on "ISCHEMIA". If you are interested to submit a manuscript, please contact us at info@discoveriesjournals.org

  • September 2014 | Special Issue

    DISCOVERIES just publish the SPECIAL ISSUE entitled "CELL SECRETION & MEMBRANE FUSION" in September 2014. Initially scheduled for publication between October 2014-March 2015, this issue was successfully published earlier than scheduled. 

    Special Issue
  • April 2014 | Indexed by Google Scholar

    All our published articles are now indexed by Google Scholar! First citations to Discoveries articles are included! Search for the article's title (recommended) or the authors:

    Google Scholar Search
  • 2014 | DISCOVERIES

    DOIs (Digital Object Identifiers) are now assigned to all our published manuscripts in Discoveries. DOI uniquely identifies an article and is provided by CrossRef.

    CrossRef
  • July 2013 | Manuscript Submission

    Submit your manuscript FREE, FAST and EASY ! (in less than 1 minute)! There are NO fees for the manuscript submission or publishing of the accepted manuscripts.
    read more

  • July 2013 | DISCOVERIES

    We are now ACCEPTING MANUSCRIPTS for publishing in DISCOVERIES. We aim publishing a small number of high impact experimental articles & reviews (around 40/year) to maintain a high impact factor. Domains of interest: all areas related to Medicine, Biology and Chemistry ...

    read more
Member Login
Free Registration Click here to sign up
Copyright © 2013 Applied Systems. All Rights Reserved.