
DISCOVERIES (ISSN 2359-7232), 2015, January-March issue
Uzoni A, Ciobanu O, Sandu RE, Buga AM, Popa-Wagner A. Life style, Perfusion deficits and Co-morbidities Precipitate Inflammation and Cerebrovascular Disorders in Aged Subjects. Discoveries 2015, Jan-Mar; 3(1): e39. DOI: 10.15190/d.2015.31
Submitted: March 09, 2015; Revised: March 27, 2015; Accepted: March 27, 2015; Published: March 31, 2015;
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Life style, Perfusion deficits and Co-morbidities Precipitate Inflammation and Cerebrovascular Disorders in Aged Subjects
Adriana Uzoni (1,4), Ovidiu Ciobanu (2,3), Raluca Elena Sandu (2), Ana Maria Buga (1,2), Aurel Popa-Wagner (1,2,*)
(1) Department of Psychiatry, University of Medicine Rostock, Germany
(2) Center of Clinical and Experimental Research, University of Medicine and Pharmacy, Craiova, Romania
(3) Department of Psychiatry, University Medicine of Saarland, Homburg/Saar, Germany
(4) Biochemistry Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
*Correspondence to: Aurel Popa-Wagner, MD, PhD, Department of Psychiatry, University of Medicine Rostock, Gehlsheimerstr. 20, 18147 Rostock, Germany. Phone: +49-381-494-9686; Fax: +49-381-494-9639; E-mail: aurel.popa-wagner@med.uni-rostock.de
Abstract
Cerebrovascular diseases represent 2nd leading cause of death worldwide. Understanding how genetic predispositions and their interaction with environmental factors affect cerebrovascular diseases is fundamental for prevention, diagnosis and for the development of safe and efficient therapies. Cerebrovascular diseases have not only a very high mortality rate, but also results in debilitating neurological impairments or permanent disability in survivors associated with huge economic losses. Among the women and men individuals with a low-risk lifestyle (smoking, exercising daily, consuming a prudent diet including moderate alcohol and having a healthy weight during mid-life) had a significantly lower risk of stroke than individuals without a low-risk lifestyle. Current review focuses on determining the relationship between diet, as an important component of ‘life style’, aging and cerebrovascular diseases.This review may help to unravel biological mechanisms linking lifestyle, diet-induced, metabolic inflammation, aging and cerebral hypoperfusion to development of cerebrovascular diseases, a prerequisite for development of science-based preventive strategies needed to combat the major public health challenges like obesity and stroke
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References
1. Olesen J, Gustavsson A, Svensson M, Wittchen HU, Jönsson B. CDBE2010 study group et al. The economic cost of brain disorders in Europe. Eur J Neurol.2012; 19:155-162.
2. Sivenius J, Torppa J, Tuomilehto J, Immonen-Räihä P, Kaarisalo M, Sarti C et al. Modelling the burden of stroke in Finland until 2030. Int J Stroke 2009; 4: 340-345.
3. Bonita R, Beaglehole R. Recovery of motor function after stroke. Stroke 1988; 19: 1497-1500.
4. Burn J, Dennis M, Bamford J, Sandercock P, Wade D, Warlow C. Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project. Stroke 1994; 25: 333-337.
5. Appelros P, Nydevik I, Viitanen M. Poor Outcome After First-Ever Stroke. Predictors for Death, Dependency, and Recurrent Stroke Within the First Year. Stroke 2003; 34(1): 122-126.
6. Donnan GA, Davis SM. Breaking the 3 h barrier for treatment of acute ischaemic stroke. Lancet Neurol. 2008; 7(11): 981-982.
7. Sarti C, Rastenyte D, Cepaitis Z, Tuomilehto J. International trends in mortality from stroke 1968 to 1994. Stroke 2000; 31(7): 1588-1601.
8. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA 2002; 288(20): 2569-2578.
9. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010; 72: 219-246.
10. Poulsen P, Ohm Kyvik K, Vaag A, Beck-Nielen H. Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance ± a population-based twin study. Diabetologia 1999; 42: 139-145.
11. Cornelis MC, Hu FB. Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges. Annu Rev Nutr. 2012; 32:245-259.
12. http://www.genome.gov/gwastudies/
13. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015; 518(7538): 197-206.
14. Shungin D, Winker TW, Croteau- Chonka DC, Ferreira T, Locke AE, Mägi R et al. New genetic loci link adipocity and insulin biology to body fat distribution. Nature 2015; 518(7538): 187-196.
15. Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IK, Brown IJ et al. Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol. 2010; 63(9): 970-979.
16. Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010; 42(2): 137-141.
17. Teslovich TM, Musunuru K, Smith AV, Edmondson A, Ioannis M. Stylianou IM, Koseki M et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466(7307): 707-713.
18. Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature 2011; 477(7362): 54-60.
19. Kettunen J, Tukiainen T, Sarin AP, Alonso AO, Tikkanen E, Lyytikäinen LP et al., Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet. 2012; 44(3): 269-276.
20. Olsen TS, Dehlendorff C, Petersen HG, Andersen KK. Body mass index and poststroke mortality. Neuroepidemiology 2008; 30:93-100.
21. Towfighi A, Ovbiagele B. The impact of body mass index on mortality after stroke. Stroke 2009; 40: 2704-2708.
22. Vemmos K, Ntaios G, Spengos K, Savvari P, Vemmou A, Pappa T, et al. Association between obesity and mortality after acute first-ever stroke: the obesity-stroke paradox. Stroke 2011; 42: 30-36.
23. Ovbiagele B, Bath PM, Cotton D, Vinisko R, Diener HC. Obesity and recurrent vascular risk after a recent ischemic stroke. Stroke 2011;42: 3397-3402.
24. Andersen KK, Olsen TS. The obesity paradox in stroke: lower mortality and lower risk of readmission for recurrent stroke in obese stroke patients. Int J Stroke 2015; 10: 99-104.
25. Ryu WS, Lee SH, Kim CK, Yoon BW. Body mass index, initial neurological severity and long-term mortality in ischemic stroke. Cerebrovasc Dis. 2011; 32: 170-176.
26. Lu Zhao, Wanliang Du. Favorable Functional Recovery in Overweight Ischemic Stroke Survivors: Findings from the China National Stroke Registry. Journal of Stroke and Cerebrovascular Diseases. 2014; 23: e201-e206.
27. Burke DT, Al-Adawi S. Effect of Body Mass Index on Stroke Rehabilitation. J Stroke Cerebrovasc Dis. 2014; 23(3): e201-206.
28. Chiquete, E, Cantú-Brito C. Obesity paradox and functional recovery in first-ever acute ischemic stroke survivors: The PREMIER study. Rev Neurol. 2010; 51: 705-713.
29. Kalichman L, Rodrigues B, Gurvich D, Israelov Z, Spivak E. Impact of patient’s weight on stroke rehabilitation results. Am J Phys Med Rehabil. 2007;86:650-655.
30. Razinia T, Saver JL, Liebeskind DS, Ali LK,Buck B, Ovbiagele B. Body mass index and hospital discharge outcomes after ischemic stroke. Arch Neurol 2007;64:388-391.
31. Tanizaki Y, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Shinohara N et al. Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama study. Stroke 2000; 31: 2616-2622.
32. Downes CE, Crack PJ. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol 2010; 160: 1872-1888.
33. Ransohoff RM, Cardona AE. The myeloid cells of the central nervous system parenchyma. Nature 2010; 468: 253-62.
34. Becker KJ, Kalil AJ, Tanzi P, Zierath DK, Savos AV, Gee JM et al. Autoimmune responses to the brain after stroke are associated with worse outcome. Stroke 2011; 42: 2763-2769.
35. Henry C, Huang Y, Wynne AM, Godbout JP. Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both proinflammatory IL-1[beta] and anti-inflammatory IL-10 cytokines. Brain Behav Immun. 2009; 23: 309–317.
36. Palin K, Cunningham C, Forse P, Perry VH, Platt N. Systemic inflammation switches the inflammatory cytokine profile in CNS wallerian degeneration. Neurobiol Dis. 2009; 30: 19–29.
37. Bilbo SD, Schwarz JM. Early-life programming of later-life brain and behavior: A critical role for the immune system. Front Behav Neurosci. 2009; 3:14.
38. Murray C, Sanderson DJ, Barkus C, Deacon RMJ, Rawlins JNP, Bannerman DM et al. Systemic inflammation induces acute working memory deficits in the primed brain: Relevance for delirium. Neurobiol Aging 2010; 33: 603–616.
39. Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci. 2005; 25: 9275–9284.
40. Godbout JP, Johnson RW. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Neurol Clin. 2006; 24: 521–538.
41. Dilger RN, Johnson RW. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol. 2008; 84: 932–939.
42. Surtees PG, Wainwright NW, Boekholdt SM, Luben RN, Wareham NJ, Khaw KT. Major depression, C-reactive protein, and incident ischemic heart disease in healthy men and women. Psychosom Med 2008; 70: 850–855.
43. Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, Perini G et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis. 2009; 24:27–53.
44. Taylor WD, Aizenstein HJ, Alexopoulos GS. The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry. 2013 Sep;18(9):963-74.
45. Raison CL, Demetrashvili M, Capuron L, Miller AH. Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 2005; 19:105–123.
46. Ferreira ED, Romanini CV, Mori MA, de Oliveira RM, Milani H. Middle-aged, but not young, rats develop cognitive impairment and cortical neurodegeneration following the four-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion. Eur J Neurosci. 2011; 34(7): 1131-1140.
47. Walker AK, Kavelaars A, Heijnen CJ, Dantzer R. Neuroinflammation and Comorbidity of Pain and Depression. Pharmacol Rev. 2013; 66: 80-101.
48. Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 664–675.
49. Leonard BE. Inflammation, depression and dementia: are they connected? Neurochem Res. 2007; 32: 1749–1756.
50. Rojo LE, Fernández JA, Maccioni AA, Jimenez JM, Maccioni RB. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch Med Res. 2008; 39: 1–16.
51. Byers AL, Yaffe K. Depression and risk of developing dementia. Nat Rev Neurol. 2012; 7(6): 323–331.
52. Reimer MM, McQueen J, Searcy L, Scullion G, Zonta B, Desmazieres A et al. Journal of Neuroscience 2011, 31(49): 18185–18194.
53. Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Mari T, Hase Y et al. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2012; 123: 381–394.
54. Lu FP, Lin KP, Kuo HK. Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PLoS One 2009; 4(1):e4144.
55. Jorm AF. Is depression a risk factor for dementia or cognitive decline? a review. Gerontology 2000; 46(4):219-227.
56. Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 2006; 63(5):530-538.
57. Ali S, Stone MA, Peters JL, Davies MJ, Khunti K. The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis. Diabet Med 2006; 23(11):1165-1173.
58. Katon W, Lyles CR, Parker MM, Karter AJ, Hunag ES, Whitmer RA. Association of Depression With Increased Risk of Dementia in Patients With Type 2 Diabetes: the Diabetes and Aging Study. Arch Gen Psychiatry 2012; 69(4):410-417.
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