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Recent Studies on the Insulin-Secreting Porosome Complex Provide Potential Therapeutic Applications in the Treatment of Diabetes

DISCOVERIES (ISSN 2359-7232), 2015, October-December


Anderson LL. Recent Studies on the Insulin-Secreting Porosome Complex Provide Potential Therapeutic Applications in the Treatment of Diabetes. Discoveries 2015, Oct-Dec; 3(4): e51. DOI: 10.15190/d.2015.43 

Submitted: December 1st, 2015; Revised: December 2nd, 2015; Accepted: December 3rd, 2015; Published: December 4th, 2015; 

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Recent Studies on the Insulin-Secreting Porosome Complex Provide Potential Therapeutic Applications  in the Treatment of Diabetes

Lloyd L. Anderson (1,*)

(1) Department of Animal Science, College of Agriculture and Life Sciences and Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-3150, USA

*Correspondence to

Lloyd L. Anderson, PhD, Iowa State University, 2356 Kildee Hall, Ames, Iowa 50011-3150, Phone: (515) 294-5540; Fax: (515) 294-4471; E-mail: llanders@iastate.edu

Access full text of the manuscript here: 


1.    Rickels MR, Schutta MH, Markmann JF, Barker CF, Naji A, Teff KL. beta-Cell function following human islet transplantation for type 1 diabetes. Diabetes 54:100–106, 2005.

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2.    Meier JJ, Hong-McAtee I, Galasso R et al. Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver. Diabetes 55:2324–2332, 2006.

View article (DOI)  PubMed

3.     Täljedal IB, Shi CL, Rooth P. Functional aspects of mouse islets transplanted to the kidney. Diabetologia 37(Suppl. 2):S112–S116, 1994.


4.   Jena BP. Porosome discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion. J Cell Mol. Med. J. 2015 May 28. PMID: 26033351, 2015.

View article (DOI)  PubMed

5.    Jeremic A, Kelly M, Cho S-J, Stromer MH, Jena BP. Reconstituted fusion pore. Biophys. J. 85:2035-2043, 2003.

View article (DOI)  PubMed

6.    Naik AR, Lewis KT, Jena BP. The neuronal porosome complex in health and disease.  Exp. Biol. Med. (Maywood) OnlineFirst, published on August 11, 2015 as doi:10.1177/1535370215598400, 2015.

View article (DOI)  PubMed

7.    Rajagopal A, Kulkarni S, Lewis KT, Chen X, Maarouf A, Kelly CV, Taatjes DJ, Jena BP.  (2015). Proteome of the insulin-secreting Min6 porosome complex: Involvement of Hsp90 in its assembly and function. Journal of Proteomics 114:83-92, 2015.

View article (DOI)  PubMed

8.    Naik AR, Kulkarni S, Lewis KT, Taatjes DJ, Jena BP. Functional reconstitution of the insulin-secreting porosome complex in live cells.  Endocrinology 2015 Nov 2:en20151653.

View article (DOI)  PubMed

9.     Hou X, Lewis KT, Wu Q, Wang S, Chen X, Flack A, Mao G, Taatjes DJ, Sun F, Jena BP. Proteome of the porosome complex in human airways epithelia: Interaction with the cystic fibrosis transmembrane conductance regulator (CFTR). Journal of Proteomics 96:82-91, 2013.

View article (DOI)  PubMed

10.  Japaridze NJ, Okuneva VG, Qsovreli MG, Surmava AG, Lordkipanidze TG, Kiladze M, Zhvania MG. Hypokinetic stress and neuronal porosome complex in the rat brain: the electron microscopic study. Micron 43:948–63, 2012.

View article (DOI)  PubMed

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