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AMPK activation can delay aging

DISCOVERIES (ISSN 2359-7232), 2015, October-December issue

CITATION: 

Stancu AL. AMPK activation can delay aging. Discoveries 2015, Oct-Dec; 3(4): e53. DOI: 10.15190/d.2015.45

Submitted: December 27th, 2015Accepted: December 30th, 2015Published: December 31st, 2015;

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AMPK activation can delay aging

Andreea Lucia Stancu *

Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA

*Correspondence to: Andreea L. Stancu, MD, Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. E-mail: astancu@bidmc.harvard.edu

Abstract

AMPK controls the regulation of cellular homeostasis, metabolism, resistance to stress, cell survival and growth, cell death, autophagy, which are some of the most critical determinants of aging and lifespan. Specific AMPK activation was recently shown to delay aging and prolong lifespan in Drosophila melanogaster. Indirect AMPK activators, such as resveratrol, metformin and exercise, are currently in clinical trials for studying their impact on human aging-related characteristics, tissue homeostasis and metabolic dysfunctions. In this minireview, I am briefly discussing the recent advances on AMP involvement in aging and lifespan elongation.

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