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Fusion Pore: A Curious Case of Rediscovering Science

DISCOVERIES (ISSN 2359-7232), 2017, April-June issue


Mitagvaria NP. Fusion Pore: A Curious Case of Rediscovering Science. Discoveries 2017, 5(2): e73. DOI: 10.15190/d.2017.3

Submitted: April 11th, 2017; Revised: April 14th, 2017; Accepted: April 14th, 2017; Published: April 16th, 2017;

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Fusion Pore: A Curious Case of Rediscovering Science

Nodar P. Mitagvaria*

I. Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 0160 Tbilisi, Georgia;

*Correspondence to: Nodar P. Mitagvaria, PhD, ScD, Professor and Head, Department of Cerebral Circulation & Metabolism, I. Beritashvili Center of Experimental Biomedicine, 14 Gotua Street, 0162 Tbilisi, Georgia; E-mail: nodmit@gmail.com;

Access full text of the manuscript here: 


1. Chang CW, Chiang CW, Jackson MB. Fusion pores and their control of neurotransmitter and hormone release. J Gen Physiol. 2017 Mar 6;149(3):301-322.

2. Weber T, Zemelman BV, McNew JA, Westermann B, Gmachl M, Parlati F, Söllner TH, Rothman JE. SNAREpins: minimal machinery for membrane fusion.Cell. 1998 Mar 20;92(6):759-72.

3. Cho SJ, Kelly M, Rognlien KT, Cho JA, Hörber JK, Jena BP. SNAREs in opposing bilayers interact in a circular array to form conducting pores. Biophys J. 2002 Nov;83(5):2522-7.

4. Cho WJ, Jeremic A, Jena BP. Size of supramolecular SNARE complex: membrane-directed self-assembly.J Am Chem Soc. 2005 Jul 27;127(29):10156-7.

5. Jeremic A, Quinn AS, Cho WJ, Taatjes DJ, Jena BP.Energy-dependent disassembly of self-assembled SNARE complex: observation at nanometer resolution using atomic force microscopy. J Am Chem Soc. 2006 Jan 11;128(1):26-7.

6. Cho WJ, Lee JS, Zhang L, Ren G, Shin L, Manke CW, Potoff J, Kotaria N, Zhvania MG, Jena BP. Membrane-directed molecular assembly of the neuronal SNARE complex. J Cell Mol Med. 2011 Jan;15(1):31-7.

7. Hammel I, Meilijson I. Function suggests nano-structure: towards a unified theory for secretion rate, a statistical mechanics approach. J R Soc Interface. 2013 Sep 4;10(88):20130640.

8. Lee JS, Jeremic A, Shin L, Cho WJ, Chen X, Jena BP. Neuronal porosome proteome: Molecular dynamics and architecture. J Proteomics. 2012 Jul 16;75(13):3952-62.

9. Naik AR, Lewis KT, Jena BP. The neuronal porosome complex in health and disease. Exp Biol Med (Maywood). 2016 Jan;241(2):115-30.

10. Wickner W, Rizo J. A cascade of multiple proteins and lipids catalyzes membrane fusion. Mol Biol Cell. 2017 Mar 15;28(6):707-711.


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