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Functional Amyloids in Alzheimer Disease

DISCOVERIES (ISSN 2359-7232), 2017, October-December issue

CITATION: 

Lau A, Bourkas M, Lu YQQ, Ostrowski LA, Weber-Adrian D, Figueiredo C, Arshad H, Shoaei SZS, Morrone CD, Matan-Lithwick S, Abraham KJ, Wang H, Schmitt-Ulms G. Functional Amyloids and their Possible Influence on Alzheimer Disease. Discoveries 2017, Oct-Dec; 5(4): e79. DOI: 10.15190/d.2017.9

Submitted: Aug 09, 2017; Revised: Sept. 29th, 2017; Accepted: Oct. 2nd, 2017; Published: Oct. 16th, 2017;

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Functional Amyloids and their Possible Influence on Alzheimer Disease

Angus Lau (1, 2), Matthew Bourkas (1, 2), Yang Qing Qin Lu (1), Lauren Anne Ostrowski (1), Danielle Weber-Adrian (1), Carlyn Figueiredo (1), Hamza Arshad (1, 2), Seyedeh Zahra Shams Shoaei (1), Christopher Daniel Morrone (1), Stuart Matan-Lithwick (1), Karan Joshua Abraham (1), Hansen Wang (2,*), Gerold Schmitt-Ulms (1, 2,*) 

(1) Department of Laboratory Medicine & Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

(2) Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Centre, 6th Floor, 60 Leonard Avenue, Toronto, Ontario M5T 2S8, Canada.


*Corresponding author: Dr. Hansen Wang, PhD and Dr. Gerold Schmitt-Ulms, PhD Tanz Centre for Research in Neurodegenerative Diseases, Krembil Discovery Centre, 6th floor, 60 Leonard Ave, Toronto, M5T 2S8 Ontario, Canada. Phone: (416) 507-6864, Fax: (416) 603-6435, Emails: hansen.wang@utoronto.ca, g.schmittulms@utoronto.ca

Abstract

Amyloids play critical roles in human diseases but have increasingly been recognized to also exist naturally. Shared physicochemical characteristics of amyloids and of their smaller oligomeric building blocks offer the prospect of molecular interactions and crosstalk amongst these assemblies, including the propensity to mutually influence aggregation. A case in point might be the recent discovery of an interaction between the amyloid β peptide (Aβ) and somatostatin (SST). Whereas Aβ is best known for its role in Alzheimer disease (AD) as the main constituent of amyloid plaques, SST is intermittently stored in amyloid-form in dense core granules before its regulated release into the synaptic cleft. This review was written to introduce to readers a large body of literature that surrounds these two peptides. After introducing general concepts and recent progress related to our understanding of amyloids and their aggregation, the review focuses separately on the biogenesis and interactions of Aβ and SST, before attempting to assess the likelihood of encounters of the two peptides in the brain, and summarizing key observations linking SST to the pathobiology of AD. While the review focuses on Aβ and SST, it is to be anticipated that crosstalk amongst functional and disease-associated amyloids will emerge as a general theme with much broader significance in the etiology of dementias and other amyloidosis.

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    Submit your manuscript FREE, FAST and EASY ! (in less than 1 minute)! There are NO fees for the manuscript submission or publishing of the accepted manuscripts.
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  • July 2013 | DISCOVERIES

    We are now ACCEPTING MANUSCRIPTS for publishing in DISCOVERIES. We aim publishing a small number of high impact experimental articles & reviews (around 40/year) to maintain a high impact factor. Domains of interest: all areas related to Medicine, Biology and Chemistry ...

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