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FDA Approved Antibacterial Drugs (2015-2017)

DISCOVERIES (ISSN 2359-7232), 2018, January-March issue


Andrei S, Valeanu L, Chirvasuta R, Stefan MG. New FDA approved antibacterial drugs: 2015-2017. Discoveries 2018, Jan-Mar; 6(1): e81. DOI: 10.15190/d.2018.1

Submitted: March 29, 2018; Revised: March 31, 2018; Accepted: April 3, 2018; Published: April 4, 2018;

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New FDA approved antibacterial drugs: 2015-2017

Stefan Andrei (1,#,*), Liana Valeanu (2,3,#), Radu Chirvasuta (4), Mihai-Gabriel Stefan (2,3)

(1) Intensive Care Unit, Centre Hospitalier Lyon Sud, Pierre Benite, France 

(2) Department of Cardiac Anesthesia and Intensive care, Emergency Institute for Cardiovascular Diseases “Prof. C.C. Iliescu” Bucharest, Romania 

(3) Carol Davila University of Medicine and Pharmacy, Bucharest, Romania  

(4) Anaesthetics Department, Lister Hospital, Stevenage, UK

# These authors contributed equally to this manuscript

*Corresponding author: Stefan Andrei, MD, Intensive Care Unit, Centre Hospitalier Lyon Sud, Pierre Benite, France, stefan.m.andrei@gmail.com


Increasing bacterial resistance to antibiotics is a worldwide ongoing issue. Urgent need for new antibacterial agents has resulted in significant research efforts, with new molecules proposed for use in clinical practice. However, many groups highlight that this process does not have an optimal rhythm and efficacy, to fully combat highly adaptive germs, particularly in the intensive care units. 

This review focuses on the last three years of novel FDA approved antibacterial agents (2015-2017): ceftazidime/avibactam, obiltoxaximab, bezlotoxumab, delafloxacin, meropenem/vaborbactam, ozenoxacin. Ceftazidime/avibactam and meropenem/ vaborbactam are new players in the field of resistant bacteria treatment. Ceftazidime/avibactam is validated in selected patients with complicated urinary or intra-abdominal infections, hospital and ventilator-associated pneumonia. Meropenem/ vaborbactam gained approval for the cases of complicated urinary tract infections. Other potential indications are under investigation, widened and validated by future studies. Obiltoxaximab is a monoclonal antibody that can be used in the prevention and treatment of inhalational anthrax. Bezlotoxumab monoclonal antibody is an useful and specific tool for the management of recurrent Clostridium difficile infection. Delafloxacin is approved for patients with acute skin or skin structure infections.

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