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COVID-19 therapy and prevention

DISCOVERIES (ISSN 2359-7232), 2020, July-September issue

CITATION: 

Elie CR. COVID-19 therapy and prevention. Discoveries 2020, 8(3): e113. DOI: 10.15190/d.2020.10


Submitted: July 28, 2020; Revision: August 24, 2020; Accepted: August 24 2020; Published: September 10, 2020; 

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COVID-19 therapy and prevention

Claude-Rosny Elie *

Department of Experimental Sciences, Université de Saint-Boniface, Winnipeg, Canada


*Corresponding author: Dr. Claude-Rosny Elie, Department of Experimental Sciences, Université de Saint-Boniface, 200 de la Cathédrale Avenue, Winnipeg, MB R2H 0H7, Canada; Phone: (204) 237-1818 # 415; Email: celie@ustboniface.ca.

Abstract

Since the outbreak of the new coronavirus pneumonia (COVID-19) in December 2019, more than 23 million people worldwide have been diagnosed with SARS-CoV-2. In response to this pandemic, a global mobilization of scientific, industrial and political support has ensued. However, more than 8 months later, as studies multiply and several governments are embarking on a resumption of their activities, the threat still remains. Our efforts to understand the evolution of the virus and the means to defeat it, at the dawn of a possible new wave, have raised more questions than provided clear and unequivocal answers. Compared to diseases caused by previously known human coronavirus, COVID-19 shows higher transmissibility, as a matter of fact “deeply concerning” cases continue to increase. Under these circumstances, and based on the information we have collected so far, this paper provides an overview of the epidemiological status of COVID-19 by considering, first through comparisons with other coronaviruses, similarities that may guide prevention measures and potentially effective therapies. From this starting point, we aimed to discuss the evidence around the efficacy of masks and respirators for different group of the population. Finally, we address therapeutic aspects including perspectives of vaccines and some antimicrobial agents such as remdesivir, favipiravir, chloroquine, hydroxychloroquine in combination with azithromycin and immunomodulators.

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References

1. Organization WH. Naming the coronavirus disease (COVID-19) and the virus that causes it. 2020. Accessed: 2020, June 20. Available from: https://www.who.int/ emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it
2. Zhu S, Guo X, Geary K, Zhang D. Emerging Therapeutic Strategies for COVID-19 patients. Discoveries (Craiova) 2020, 8(1): e105.
3. Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020, 395(10223): 514-523.
4. Ghebreyesus TA. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. Speeches 2020. Accessed: 2020 June 20. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020
5. Organization WH. WHO Coronavirus Disease (COVID-19) Dashboard. 2020. Accessed: 2020 August 24. Available from:  https://covid19.who.int/
6. Nurses ICo. International Council of Nurses calls for data on healthcare worker infection rates and deaths. 2020. Accessed: 2020 June 25. Available from: https://www.icn.ch/sites/default/files/inline-files/PR_20 _Infections%20and%20deaths%20from%20COVID-19%20among%20nurses.pdf
7. Chan JF, Yip CC, To KK, Tang TH, Wong SC, Leung KH, et al. Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens. J Clin Microbiol 2020, 58(5).
8. D'Ardes D, Boccatonda A, Rossi I, Pontolillo M, Cocco G, Schiavone C, et al. Long-term Positivity to SARS-CoV-2: A Clinical Case of COVID-19 with Persistent Evidence of Infection. Eur J Case Rep Intern Med 2020, 7(6): 001707.
9. Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, et al. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. Acta Pharm Sin B 2020.
10. Zhou W. The Coronavirus Prevention Handbook: 101 Science-Based Tips That Could Save Your Life. Skyhorse Publishing: United States of America, 2020.
11. Goldsmith CS, Tatti KM, Ksiazek TG, Rollin PE, Comer JA, Lee WW, et al. Ultrastructural characterization of SARS coronavirus. Emerg Infect Dis 2004, 10(2): 320-326.
12. Goldsmith CS, Miller SE. Modern uses of electron microscopy for detection of viruses. Clin Microbiol Rev 2009, 22(4): 552-563.
13. Qinfen Z, Jinming C, Xiaojun H, Huanying Z, Jicheng H, Ling F, et al. The life cycle of SARS coronavirus in Vero E6 cells. J Med Virol 2004, 73(3): 332-337.
14. Kim D, Lee JY, Yang JS, Kim JW, Kim VN, Chang H. The Architecture of SARS-CoV-2 Transcriptome. Cell 2020, 181(4): 914-921 e910.
15. Han Y, Du J, Su H, Zhang J, Zhu G, Zhang S, et al. Identification of Diverse Bat Alphacoronaviruses and Betacoronaviruses in China Provides New Insights Into the Evolution and Origin of Coronavirus-Related Diseases. Front Microbiol 2019, 10: 1900.
16. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020, 395(10224): 565-574.
17. Lee EYP, Ng MY, Khong PL. COVID-19 pneumonia: what has CT taught us? Lancet Infect Dis 2020, 20(4): 384-385.
18. DeDiego ML, Nieto-Torres JL, Jimenez-Guardeno JM, Regla-Nava JA, Castano-Rodriguez C, Fernandez-Delgado R, et al. Coronavirus virulence genes with main focus on SARS-CoV envelope gene. Virus Res 2014, 194: 124-137.
19. Ahmed SF, Quadeer AA, McKay MR. Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies. Viruses 2020, 12(3).
20. Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci 2020, 63(3): 457-460.
21. Letko M, Munster V. Functional assessment of cell entry and receptor usage for lineage B beta-coronaviruses, including 2019-nCoV. bioRxiv 2020.
22. Hoffmann M, Kleine-Weber H, Krüger N, Müller M, Drosten C, Pöhlmann S. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. bioRxiv 2020: 2020.2001.2031.929042.
23. Lam TT, Jia N, Zhang YW, Shum MH, Jiang JF, Zhu HC, et al. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature 2020.
24. Li X, Zai J, Zhao Q, Nie Q, Li Y, Foley BT, et al. Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2. J Med Virol 2020, 92(6): 602-611.
25. Wahba L, Jain N, Fire AZ, Shoura MJ, Artiles KL, McCoy MJ, et al. An Extensive Meta-Metagenomic Search Identifies SARS-CoV-2-Homologous Sequences in Pangolin Lung Viromes. mSphere 2020, 5(3).
26. Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, et al. Author Correction: A new coronavirus associated with human respiratory disease in China. Nature 2020, 580(7803): E7.
27. Zhang T, Wu Q, Zhang Z. Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Curr Biol 2020, 30(7): 1346-1351 e1342.
28. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020, 579(7798): 270-273.
29. Jan H, Faisal S, Khan A, Khan S, Usman H, Liaqat R, et al. COVID-19: Review of Epidemiology and Potential Treatments Against 2019 Novel Coronavirus. Discoveries (Craiova) 2020, 8(2): e108.
30. Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA 2020.
31. Shiu EYC, Leung NHL, Cowling BJ. Controversy around airborne versus droplet transmission of respiratory viruses: implication for infection prevention. Curr Opin Infect Dis 2019, 32(4): 372-379.
32. Tellier R, Li Y, Cowling BJ, Tang JW. Recognition of aerosol transmission of infectious agents: a commentary. BMC Infect Dis 2019, 19(1): 101.
33. Wei J, Li Y. Airborne spread of infectious agents in the indoor environment. Am J Infect Control 2016, 44(9 Suppl): S102-108.
34. Quality FICfIA. Transmission of Viruses in indoor Air: HVAC System Protection Options. In: Agency EP, editor. USA; June 2009.
35. Heffernan JM, Smith RJ, Wahl LM. Perspectives on the basic reproductive ratio. J R Soc Interface 2005, 2(4): 281-293.
36. Guerra FM, Bolotin S, Lim G, Heffernan J, Deeks SL, Li Y, et al. The basic reproduction number (R0) of measles: a systematic review. Lancet Infect Dis 2017, 17(12): e420-e428.
37. Petrosillo N, Viceconte G, Ergonul O, Ippolito G, Petersen E. COVID-19, SARS and MERS: are they closely related? Clin Microbiol Infect 2020, 26(6): 729-734.
38. Mahase E. Coronavirus: covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate. BMJ 2020, 368: m641.
39. Mercatelli D, Giorgi FM. Geographic and Genomic Distribution of SARS-CoV-2 Mutations. 2020, 11(1800).
40. Zhang L, Jackson CB, Mou H, Ojha A, Rangarajan ES, Izard T, et al. The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. bioRxiv 2020.
41. Nishiura H, Kobayashi T, Yang Y, Hayashi K, Miyama T, Kinoshita R, et al. The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights. J Clin Med 2020, 9(2).
42. Li R, Pei S, Chen B, Song Y, Zhang T, Yang W, et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2). Science 2020, 368(6490): 489-493.
43. Breslin N, Baptiste C, Miller R, Fuchs K, Goffman D, Gyamfi-Bannerman C, et al. Coronavirus disease 2019 in pregnancy: early lessons. Am J Obstet Gynecol MFM 2020, 2(2): 100111.
44. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med 2020, 382(12): 1177-1179.
45. Wolfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Muller MA, et al. Virological assessment of hospitalized patients with COVID-2019. Nature 2020, 581(7809): 465-469.
46. Morawska L, Milton DK. It is Time to Address Airborne Transmission of COVID-19. Clinical Infectious Diseases 2020, ciaa939. DOI: 10.1093/cid/ciaa939.
47. MacIntyre CR, Chughtai AA. A rapid systematic review of the efficacy of face masks and respirators against coronaviruses and other respiratory transmissible viruses for the community, healthcare workers and sick patients. Int J Nurs Stud 2020, 108: 103629.
48. Bao L, Deng W, Huang B, Gao H, Liu J, Ren L, et al. The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Nature 2020, 583(7818): 830-833.
49. Journal BM. Coronavirus disease 2019 (COVID-19) History and exam. 2020. Accessed: 2020 August 21. Available from: https://bestpractice.bmj.com/topics/engb/ 3000168/history-exam
50. Novavax. Evaluation of the Safety and Immunogenicity of a SARS-CoV-2 rS (COVID-19) Nanoparticle Vaccine With/Without Matrix-M Adjuvant. 2020. Accessed: 2020 July 27. Available from: https://ClinicalTrials.gov/show/NCT04368988
51. Ltd CBAP. SCB-2019 as COVID-19 Vaccine. 2020. Accessed: 2020 July 27. Available from: https://ClinicalTrials.gov/show/NCT04405908
52. AnGes I. Study of COVID-19 DNA Vaccine (AG0301-COVID19). 2020. Accessed: 2020 August 24. https://ClinicalTrials.gov/show/NCT04463472
53. Institute of Biotechnology AoMMS, PLA of China A Phase II Clinical Trial to Evaluate the Recombinant Vaccine for COVID-19 (Adenovirus Vector). 2020. Accessed: 2020 July 27. Available from: https://ClinicalTrials.gov/show/NCT04341389
54. Oxford Uo. Investigating a Vaccine Against COVID-19. 2020. Accessed: 2020 July 27. Available from: https://ClinicalTrials.gov/show/NCT04400838
55. SE B. Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Adults. 2020. Accessed: 2020 July 27. Available from: https://ClinicalTrials.gov/show/NCT04368728
56. Sinovac Research and Development Co. L. Safety and Immunogenicity Study of Inactivated Vaccine for Prevention of SARS-CoV-2 Infection (COVID-19). 2020. Accessed: 2020 July 27. Available from: https://ClinicalTrials.gov/show/NCT04383574
57. Chen W.  A Phase III clinical trial for inactivated novel coronavirus pneumonia (COVID-19) vaccine (Vero cells). 2020. Accessed: 2020 July 27. Available from: http://www.chictr.org.cn/showprojen.aspx?proj=56651
58. ModernaTX I. A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19.  2020. Accessed: 2020 July 27. Available from: https://ClinicalTrials.gov/show/NCT04470427
59. Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 2016, 531(7594): 381-385.
60. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020, 30(3): 269-271.
61. Pruijssers AJ, George AS, Schafer A, Leist SR, Gralinksi LE, Dinnon KH, 3rd, et al. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Rep 2020, 32(3): 107940.
62. Maffei D. Gilead Presents Additional Data on Investigational Antiviral Remdesivir for the Treatment of COVID-19 In: Gilead Sciences I, editor. FOSTER CITY, California,USA: Gilead Sciences, Inc.; 2020.
63. Furuta Y, Komeno T, Nakamura T. Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. Proc Jpn Acad Ser B Phys Biol Sci 2017, 93(7): 449-463.
64. Hayden FG, Shindo N. Influenza virus polymerase inhibitors in clinical development. Curr Opin Infect Dis 2019, 32(2): 176-186.
65. Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov 2020, 19(3): 149-150.
66. Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther 2020, 14(1): 58-60.
67. Xu X, Han M, Li T, Sun W, Wang D, Fu B, et al. Effective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci U S A 2020, 117(20): 10970-10975.
68. Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med 2020, 46(5): 846-848.
69. Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis 2020.
70. Chen X, Zhao B, Qu Y, Chen Y, Xiong J, Feng Y, et al. Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. Clin Infect Dis 2020.
71. Somers EC, Eschenauer GA, Troost JP, Golob JL, Gandhi TN, Wang L, et al. Tocilizumab for treatment of mechanically ventilated patients with COVID-19. medRxiv 2020.
72. Health NIo. NIH clinical trial testing remdesivir plus interferon beta-1a for COVID-19 treatment begins. 2020.
73. Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the Treatment of Covid-19 - Preliminary Report. N Engl J Med 2020.
74. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020, 8(5): 475-481.
75. Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, et al. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nature medicine 2002, 8(5): 473-479.
76. Group RC, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, et al. Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med 2020.
77. Bhimraj A, Morgan RL, Shumaker AH, Lavergne V, Baden L, Cheng VC, et al. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. Clin Infect Dis 2020.
78. Vincent MJ, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, et al. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virology Journal 2005, 2(1): 69.
79. Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends 2020, 14(1): 72-73.
80. Kalil AC. Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics. JAMA 2020, 323(19): 1897-1898.
81. Multicenter collaboration group of Department of S, Technology of Guangdong P, Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus p. [Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi 2020, 43(3): 185-188.
82. Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery 2020, 6(1): 16.
83. Rynda-Apple A, Robinson KM, Alcorn JF. Influenza and Bacterial Superinfection: Illuminating the Immunologic Mechanisms of Disease. Infect Immun 2015, 83(10): 3764-3770.
84. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents 2020: 105949.
85. Raoult D, Houpikian P, Tissot Dupont H, Riss JM, Arditi-Djiane J, Brouqui P. Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine. Arch Intern Med 1999, 159(2): 167-173.
86. Singh AK, Singh A, Shaikh A, Singh R, Misra A. Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries. Diabetes Metab Syndr 2020, 14(3): 241-246.
87. USA FDA. Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Chloroquine and Hydroxychloroquine. 2020. Accessed: 2020 August 21. Available from: https://www.fda.gov/news-events/ press-announcements/coronavirus-covid-19-update-fda-revokes-emergency-use-authorization-chloroquine-and
88. Qaseem A, Yost J, Etxeandia-Ikobaltzeta I, Humphrey LL. Update Alert 2: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points from the American College of Physicians. Ann Intern Med 2020, M20-3862.

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