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Four-Dimensional Echocardiography in Coronary Sinus Evaluation

DISCOVERIES (ISSN 2359-7232), 2020, October-December issue


Glodeanu A, Cherata DA, Popa RT, Popa DL, Barbulescu L, Zaharie SI, Golli AL, Glodeanu MVFour-Dimensional Echocardiography Is an Accurate Tool for Coronary Sinus Evaluation in Patients with Persistent Left Superior Vena Cava Diagnosis. Discoveries 2020, 8(4): e118. DOI: 10.15190/d.2020.15

Submitted: July 23, 2020; Revised: October 31, 2020; Accepted: November 03, 2020; Published: December 09, 2020; 

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Four-Dimensional Echocardiography Is an Accurate Tool for Coronary Sinus Evaluation in Patients with Persistent Left Superior Vena Cava Diagnosis

Adina Glodeanu (1), Diana Alexandra Cherata (2,*), Radu Teodoru Popa (3), Didi Liliana Popa (4), Linda Barbulescu (1), Sorin Ioan Zaharie (1), Andreea Loredana Golli (1), Mihnea Valeriu Glodeanu (4)

(1) University of Medicine and Pharmacy of Craiova, Romania

(2) University of Medicine and Pharmacy of Craiova, Calafat Municipal Hospital, Romania

(3) Filantropia Municipal Hospital, Craiova, Romania 

(4) University of Craiova, Romania

*Corresponding author: Diana Alexandra Cherata, MD Cardiologist, PhD, University of Medicine and Pharmacy of Craiova, Calafat Municipal Hospital, Traian Street, Nr. 5, Calafat, 205200, Romania; Email diana_cherata@yahoo.com; Phone: +40733674763.


Persistent left superior vena cava (PLSVC) is a rare vascular congenital anomaly yet the most common for the thoracic venous system. Usually asymptomatic, PLSVC is commonly diagnosed when echocardiography or other cardiovascular imaging is performed. Due to venous drainage abnormality, PLSVC is frequently associated with other anomalies of the intrinsic heart’s conduction system, leading to tachy- or brady- arrhythmias.

We present the case of a patient with 20 years history of supraventricular rhythm disorders diagnosed with isolated PLSVC. Furthermore, we discuss the diagnostic approach providing insights into four-dimensional echocardiography (4DE) evaluation for PLSVC diagnosis, assuming that there is a direct correlation between coronary sinus dilatation caused by abnormal venous return and supraventricular rhythm disorders. We highlight that correct understanding of the pathophysiology of PLSVC will lead to a reduction in unnecessary and potentially harmful testing, to a shorter diagnostic time and to a financial resource saving, as a whole.

Access full text of the manuscript here: 


1. Goyal SK, Punnam SR, Verma G, Ruberg FL. Persistent left superior vena cava: a case report and review of literature. Cardiovasc Ultrasound. 2008;6:50. Published 2008 Oct 10. 
2. Uçar , Paşaoğlu L, Ciçekçioğlu H, Vural M, Kocaoğlu I, Aydoğdu S., Persistent left superior vena cava with absent right superior vena cava: a case report and review of the literature. Cardiovasc J Afr. 2010 May-Jun; 21(3):164-6.
3. Kobayashi M, Ichikawa T, Koizumi J, Hashimoto J, Yamamuro H, Hara T, Nomura T, Kanda S, Imai Y.Aberrant Left Brachiocephalic Vein versus Persistent Left Superior Vena Cava without Bridging Vein in Adults: Evaluation on Computed Tomography. Ann Vasc Dis. 2018 Dec 25; 11(4):535-541. 
4. Kula S, Cevik A, Sanli C, Pektas A, Tunaoglu FS, Oguz AD, Olgunturk R., Persistent left superior vena cava: experience of a tertiary health-care center. Pediatr Int. 2011 Dec;53(6):1066-9. 
5. Sheikh AS, Mazhar S.,Persistent left superior vena cava with absent right superior vena cava: review of the literature and clinical implications. Echocardiography. 2014 May; 31(5):674-9. 
6. Morgan L.G., Gardner J., Calkins J, The Incidental Finding of a Persistent Left Superior Vena Cava: Implications for Primary Care Providers—Case and Review. Case Reports in Medicine. 2015, Article ID 198754. 
7. Voci P, Luzi G, Agati L., Diagnosis of persistent left superior vena cava by multiplane transesophageal echocardiography. Cardiologia. 1995 Apr; 40(4):273-5.
8. Conca C, Faletra F, Chioncel O, Sorgente A, Pasotti E, Pedrazzini G, Moccetti T, Auricchio A, Coronary Sinus Visualization by 3-dimensional Real-Time Echocardiography. J Am Soc Echocardiogr. 2008 Apr;21(4):371-6.
9. Surkova, E., Muraru, D., Aruta, P., Romeo G., Bidviene J., Cherata D., Badano L. P. Current Clinical Applications of Three-Dimensional Echocardiography: When the Technique Makes the Difference. Curr Cardiol Rep. 2016 Nov;18(11):109. 
10.Rose ME, Gross L, Protos A. Transvenous pace-maker implantation by way of an anomalous left superior vena cava. J Thorac Cardiovasc Surg. 1971 Dec; 62(6):965-6.
11. Hsu LF, Ja ̈ıs P, Keane D et al. Atrial fibrillation originating from persistent left superior vena cava. Circulation 2004; 109(7). 828–832.  
12. Demosthenes G Katritsis 1 The Coronary Sinus: Passive Bystander or Source of Arrhythmia? Heart Rhythm. 2004 May;1(1):113-6.

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