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Sequelae of COVID-19 and mental health implications

DISCOVERIES (ISSN 2359-7232), 2021, October-December issue


Walia N, Lat JO, Tariq R, Tyagi S, Qazi AM, Salari SW, Jafar A, Kousar T, Bieniek S. Post-acute sequelae of COVID-19 and the mental health implications. Discoveries 2021, 9(4): e140. DOI: 10.15190/d.2021.19

Submitted: Oct. 27, 2021; Revized: Dec. 04, 2021; Accepted: Dec. 16, 2021; Published: Dec. 31, 2021.

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Post-acute sequelae of COVID-19 and the mental health implications

Namrata Walia (1), Jessica Olivia Lat (2), Rabeet Tariq (3), Surbhi Tyagi (4), Adam Manzoor Qazi (5), Syeda Wajiha Salari (6), Amina Jafar (7), Tasneem Kousar (8), Sherrie Bieniek (9)

(1) Baylor College of Medicine, Houston, Texas, United States

(2) Ateneo School of Medicine and Public Health, Philippines

(3) Liaquat National Hospital and Medical College, Karachi, Pakistan 

(4) International School of Medicine, Jinan University, Guangzhou, China

(5) The Hospital for Sick Children, Toronto, Canada

(6) Rawalpindi Medical University, Pakistan

(7) King Edward Medical University, Pakistan 

(8) Foundation University Medical College, Rawalpindi, Pakistan 

(9) Larkin Community Hospital, South Miami, Florida, United States

*Corresponding authorsDr. Namrata Walia, Department of Family and Community Medicine, Baylor College of Medicine, 3701 Kirby Dr, Houston TX 77098, USA; Email: namrata.walia@bcm.edu 


Post-acute sequelae of COVID-19 (PASC) or more commonly known as Long COVID-19, is the term given to persistent symptoms 12 weeks from the initial presentation of COVID-19 infection. Several multi-organ symptoms have been reported by patients. Some common symptoms include headaches, fatigue, memory impairment and mental health complications such as anxiety and depression. People with previous psychiatric diagnosis are at greater risk of developing longer mental health implications from persistent COVID-19 symptoms. Additionally, healthcare workers are at increased risk of being long haulers leading to burnout and exhaustion. The objective of this review article is to provide comprehensive evidence from existing literature on various symptoms reported by patients experiencing Long COVID-19 and the rate of occurrence of such symptoms in different populations. A long-term disease surveillance is required to further understand the persistent symptoms or the long-term impact of this infection. 

Access full text of the manuscript here: 


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