New model predicts in-hospital complications in myocardial infarction
DISCOVERIES (ISSN 2359-7232), 2022, January-March issue
Submitted: Jan 12, 2022; Revised: Feb. 19, 2022; Accepted: Feb. 25, 2022; Published: Mar. , 2022
GO BACK to 2022, January-March issue
GO BACK to DISCOVERIES
New model predicts in-hospital complications in myocardial infarction
Geovedy Martinez-Garcia (1,*), Miguel Rodriguez-Ramos (2), Maikel Santos-Medina (3), Annia Maria Carrero-Vazquez (1), Yanitsy Chipi-Rodriguez (1)
(1) Cardiology Service, Enrique Cabrera General Teaching Hospital, Havana, Cuba
(2) Cardiology Service, Camilo Cienfuegos General Teaching Hospital, Sancti Spiritus, Cuba
(3) Cardiology Service, Dr. Ernesto Guevara de La Serna General Teaching Hospital, Las Tunas, Cuba
*Corresponding authors: Geovedy Martinez-Garcia, MD, Cardiology Service, Enrique Cabrera General Teaching Hospital, Havana, Cuba; Aldabó St. and E St. No. 11117, Altahabana, Boyeros, Havana, 10800, Cuba. Phone number: (53)7643-8044; E-mail: geovedy@nauta.cu
Abstract
Introduction and Objectives: Ischemic cardiopathy constitutes the leading cause of death worldwide. Our aim was to evaluate the prognostic capacity of the leukoglycemic index as well as to create a predictive model of in-hospital complications in patients with ST elevation myocardial infarction.
Materials and Methods: This was a multicentral and cohort study, which included patients inserted in the Cuban Registry of acute myocardial infarction. The study investigated 900 patients with a validation population represented by 233 external subjects. In order to define the performance of the leukoglycemic index were evaluated the discrimination with the statistical C and the calibration by Hosmer – Lemeshow test. A model of logistic binary regression was employed in order to define the predictive factors.
Results: Optimal cut point of the leukoglycemic index to predict in-hospital complications was 1188 (sensibility 60%; specificity 61.6%; area under the curve 0.623; p < 0.001). In-hospital complications were significantly higher in the group with the leukoglycemic index ≥ 1188; a higher value was significantly associated with a higher risk to develop an in-hospital complication [RR (IC 95%) = 2.4 (1.804–3.080); p<0.001]. The predictive model proposed is composed by the following factors: age ≥ 66 years, leukoglycemic index ≥ 1188, Killip-Kimball classification ≥ II and medical history of hypertension. This scale had a good discrimination in both, the training and the validation population.
Conclusions: The leukoglycemic index possesses a low performance when used to assess the risks for in hospital complications in patients with ST elevation myocardial infarction. The new predictive model has a good performance, which can be applied to estimate risk of in-hospital complications. This model would be able to contribute to the health systems of developing countries without additional cost; it enables prediction of the patients having a higher risk of complications and a negative outcome during the hospitable admission.
Access full text of the manuscript here: Full text (pdf)
References
1. Cuba. Centro Nacional de Información de Ciencias Médicas. Biblioteca Médica Nacional. Heart diseases. Bibliomed. 2021 Feb;28(2):1-10
2. Bebb O, Hall M, Fox KAA, et al. Performance of hospitals according to the ESC ACCA quality indicators and 30-day mortality for acute myocardial infarction: national cohort study using the United Kingdom Myocardial Ischemia National Audit Project (MINAP) register. Eur Heart J. 2017 Apr 1;38(13):974–82.
3. Ministerio de Salud Pública Cuba. Dirección de registros médicos y estadísticas de salud. 2020 Statistical Yearbook of Health. Havana, 2021.
4. Zhao Sh, Murugiah K, Li N et al. Admission Glucose and in‑hospital Mortality after Acute Myocardial Infarction in Patients with or without Diabetes: A Cross-sectional Study. Chin Med J (Eng). 2017 Apr;130(7):767-75.
5. Santos MM, Barreiro AG, García RQG et al. Risk factors of hospitality mortality in patients after acute myocardial infarction. Rev Cub Cardiol Cirug Cardiovasc. 2017;23(3):27-44.
6. Issa M, Alqahtani F, Berzingi Ch et al. Impact of acute diabetes decompensation on outcomes of diabetic patients admitted with ST-elevation myocardial infarction. Diabetol Metab Syndr. 2018;10:57-65.
7. Terlecki M, Bednarek A, Kawecka-Jaszcz K et al. Acute hyperglycaemia and inflammation in patients with ST segment elevation myocardial infarction. Kardiologia Polska. 2013;71(3):260–7.
8. Akhtar N, Adil MM, Ahmed W et al. The role of leukocyte counts in patients with unstable angina pectoris or myocardial infarction: prognostic significance and correlation with plasma brain natriuretic peptide (BNP) levels. J Pak Med Assoc. 2011 Jan;61(1):51-4.
9. Guasti L, Dentali F, Castiglioni L et al. Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularization. A systematic review on more than 34,000 subjects. Thromb Haemost. 2011 Oct;106(4):591-9.
10. Quiroga W, Conci E, Zelaya F et al. Acute myocardial infarction with St-segment elevation risk stratification according to the leukoglycemic index. "Killip-Kimbal" laboratory? Rev Fed Arg Cardiol. 2010;39:29-34.
11. Santos MM, Rodríguez MR, Prohias JM, et al. Cuban registry of acute myocardial infarction (RECUIMA), the first 1000 cases. Rev Cub Cardiol Cir Cardiovasc. 2019;25 (3 Suppl 1):419-35.
12. Santos MM, Rodríguez MR, Prohias JM et al. Methodological bases of the Cuban registry of acute myocardial infarction: from utopia to reality. Rev Cub Cardiol Cir Cardiovasc. 2017;24(2):4-10.
13. Thygesen K, Alpert JS, Jaffe AS et al. Task Force for the Universal Definition of Myocardial Infarction. Fourth universal definition of myocardial infarction. Rev Esp Cardiol. 2019; 72(1):72.e1-e27.
14. Reyes P, Echeverría F, Chuquel C et al. Inflammatory theory of acute coronary syndrome: leukoglycemic index as prognostic factor. Rev Conarec. 2012;28(113):31-5.
15. Hirschson AP, Higa C, Merlo P et al. Prognostic Value of the Leukoglycemic Index in Acute Myocardial Infarction. Results from the SCAR Multicenter Registry. Rev Argent Cardiol. 2014;82:500-5
16. Martínez AS, Mendoza MR, López AG. Leukoglycemic index as predictor of complications in acute coronary syndrome. Med Crit. 2018;32(1):27-33.
17. León-Aliz E, Moreno-Martínez FL, Pérez-Fernández GA, et al. Leukoglycemic index as an in-hospital prognostic marker in patients with ST-segment elevation myocardial infarction. Clin Invest Arterioscl. 2014;26:167-174.
18. Díaz REB, Correa AMM, Reyes LMH et al. Glycosylated hemoglobin and leukoglycemic index as prognostic determinations in acute coronary syndrome. CorSalud. 2016 Jul-Sep;8(3):153-63.
19. Padilla-Cueto D, Hernández-Negrín H, Ramírez-Gómez JI et al. The leukoglycemic index is a predictor of all-cause mortality per year in Cuban patients with ST-segment elevation acute myocardial infarction. CorSalud. 2019 Jan-Mar;11(1):21-9
20. Rodríguez-Jiménez A, Fardales-Rodríguez R, Toledo-Rodríguez E et al. Leukoglycemic Index as a Prognostic Factor after Acute Myocardial Infarction with ST-segment Elevation. Rev Finlay. 2019;9(2):1-10.
News & Events Latest news from Discoveries
- 2022, April| AWARDS!
2022 Discoveries Award winning articles!
- Kinal Bhatt et al. 2021 (Larking Health System, FL, USA); Bhatt K, Agolli A, Patel MH, et al. High mortality co-infections of COVID-19 patients: mucormycosis and other fungal infections. Discoveries. 2021;9(1):e126.
27 citations in the past 1 year - $1000 prize- Hasnain Jan et al. 2020 (Quaid-i-Azam University, Pakistan); Jan H, Faisal S, Khan A, et al. COVID-19: Review of Epidemiology and Potential Treatments Against 2019 Novel Coronavirus. Discoveries. 2020;8(2):e108.
23 citations in the past 2 years - $400 prizeCongratulations! Prizes will be received by the awardees in July 2022!
- 2021, July| 2021, Jul-September
Due to the high volume of the submitted articles, both Discoveries and Discoveries Reports are experiencing processing and publication delays during the months of July-September 2021. We will get back to the normal processing and publication times starting in October 2021. Note that our editorial and administrativ work is fully funded by our publishing house at this time and we are striving to KEEP THE NO FEE/NO CHARGE strategy in place as long as possible.
- 2021, January| AWARDS!
2022 DISCOVERIES AWARDS! Discoveries will offer $1000 and $400 awards in early 2022, for the most cited (2021 ISI Citations) and visible articles published in 2018-2021.
- 2020, November| Follow us on Twitter!
You can now follow the latest Discoveries news and updates on Twitter! (@DiscoveriesNews)
- 2020, August| For Authors!
Due to a high volume of article submissions, our peer-review process takes more than usual. The pre-screening decision is released in 1-2 days, while the peer-review process lasts between 10 and 20 days.
- 2020, April | For Authors!
WE DO NOT TOLERATE ANY MISCONDUCT! Please be aware that we are testing all received articles with specialized software for PLAGIARISM and WE WILL TAKE MEASURES if your article is already published or in consideration for publication by other journals! This may result in serious professional consequences for the authors. The latest striking case is the following article which is already published and was re-submitted here.
- 2020, April | For Authors!
We are happy to let you know that all articles published in Discoveries are now included in PubMedCentral (PMC). New accepted articles will be included in PMC and PubMed within 1-2 weeks after their publication.
- 2020, January | For Authors!
Starting in January 2020, Discoveries will also consider articles submitted by Discoveries' Editorial Board members. However, only a small number of such articles (maximum 4 articles/year) will be considered for publication after the peer-review process, and the authors who are also our editors will be clearly disclosed on our website.
- 2019, September | Indexed by PMC
Discoveries is now indexed by PubMedCentral and Pubmed. The agreement with US National Library of Medicine was signed on September 10, 2019. Our next step is ISI Web of Science indexing. NOTE: previously published articles will be included on PubMed in early 2020.
- 2019, September | PubMed inclusion!
We are happy to let you know that Discoveries successfuly passed the last step (Technical Review) required for PubMedCentral and PubMed inclusion!
- 2019, July | PubMed inclusion News!
We are happy to receive positive comments from PMC/NLM-NIH regarding Discoveries' last step (Technical Review) required for PubMedCentral and PubMed inclusion. We will let you know once whole indexing process is completed.
- 2019| Sharing and Distribution!
All articles published in Discoveries are Open Access articles distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and it is not used for commercial purposes.
- 2018-2019 | For Authors!
From now on and for at least 1 year, we will only accept articles from authors that are NOT members of Discoveries' Editorial Board. All articles submitted by our editors will be immediately rejected until further notice (one accepted article was already rejected).
- 2018 | PubMed inclusion News!
Discoveries successfully passed the Scientific Quality Review by NLM-NIH for PubMedCentral and PubMed indexing. This is the first and the most important step towards PubMedCentral and PubMed indexing! The second (last) step is the Technical Review.
- 2016, April | Faster Peer-Review
Starting on April 13th 2016, all articles selected for a peer-review will receive the post peer-review decision within ~10 days. The initial pre-screening time will remain the same (48h from the submission of the manuscript). This decision will significantly accelerate the publication, with no effect on the quality of the peer-review process.
- 2016, February | Manuscript submission
Discoveries is commited to excellence, quality and high editorial standards. We are receiving an increasing number of manuscripts for which the identity of the authors/corresponding author can't be verified. Please NOTE that ALL these articles were and will be immediately REJECTED. Indicating an institutional email address is the easiest way to overcome this problem! Moreover, we do not accept any pressure on our editorial board to accept a manuscript. This results in a prompt rejection of the article.
Editorial Policies - 2016, January | Main Objective
After reaching all proposed milestones until now (including being indexed by Google Scholar in 2014), Discoveries' next Aim is PubMed indexing of all its articles (already published and upcoming). There will be no charge for the submission or publication of articles before Discoveries is indexed.
- 2015, August | Discoveries - on PubMed
We are happy to announce that our first Discoveries articles were included in PMC and PubMed. More articles (submitted by NIH funded authors) are now processed for being included.
Discoveries articles now on PubMed - 2015, April | Special Issue
DISCOVERIES published the SPECIAL ISSUE entitled "INFLAMMATION BETWEEN DEFENSE AND DISEASE: Impact on Tissue Repair and Chronic Sickness".
Special Issue on "Inflammation" - 2015 | Ischemia Collection
DISCOVERIES launched a call for papers for a Collection of Articles with focus on "ISCHEMIA". If you are interested to submit a manuscript, please contact us at info@discoveriesjournals.org
- 2014, September | Special Issue
DISCOVERIES just publish the SPECIAL ISSUE entitled "CELL SECRETION & MEMBRANE FUSION" in September 2014. Initially scheduled for publication between October 2014-March 2015, this issue was successfully published earlier than scheduled.
Special Issue - 2014, April | Indexed by Google Scholar
All our published articles are now indexed by Google Scholar! First citations to Discoveries articles are included! Search for the article's title (recommended) or the authors:
Google Scholar Search - 2014 | DISCOVERIES
DOIs (Digital Object Identifiers) are now assigned to all our published manuscripts in Discoveries. DOI uniquely identifies an article and is provided by CrossRef.
CrossRef - 2013, July | Manuscript Submission
Submit your manuscript FREE, FAST and EASY ! (in less than 1 minute)! There are NO fees for the manuscript submission or publishing of the accepted manuscripts.
read more - 2013, July | DISCOVERIES
We are now ACCEPTING MANUSCRIPTS for publishing in DISCOVERIES. We aim publishing a small number of high impact experimental articles & reviews (around 40/year) to maintain a high impact factor. Domains of interest: all areas related to Medicine, Biology and Chemistry ...
read more