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Duodenal Polyps, histopathologic spectrum.

DISCOVERIES (ISSN 2359-7232), 2022, January-March issue


Rai V, Saha A, Verma R, Jain V, Baro B. Histopathological spectrum of duodenal polyps in a retrospective ten-year study. Discoveries 2022; 10(1): e143. DOI: 10.15190/d.2022.2

Submitted: Feb. 08, 2022; Revised: Feb. 20, 2022; Accepted: Mar. 01, 2022; Published: Mar., 2022.

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Histopathological spectrum of duodenal polyps in a retrospective ten-year study

Varnika Rai (1), Anurag Saha (2), Ritu Verma (1, *), Vipul Jain (2), Bhanita Baro (2)

(1) Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, Uttar Pradesh, India

(2) Department of Pathology, Topiwala National Medical College and Nair Ch. Hospital, Mumbai, Maharashtra, India

*Corresponding authors: Dr. Ritu Verma, Professor, Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, India-226014; Email: vimalritu1@gmail.com


Introduction and Aims: Duodenal polyps are rare in patients undergoing Upper Gastrointestinal scopy. The present study is an experience of the histopathological spectrum of the duodenal polyps and its correlation with the clinical and endoscopic findings in a tertiary care centre. 

Materials and Methods: The present study is a 10-year retrospective study from the year 2011 to 2020. All the relevant clinical, endoscopic and radiologic findings were retrieved from the hospital medical records. Old histopathology slides were restained, and wherever required, special stains and immunohistochemistry (IHC) was done on them. All the cases were reviewed. The present study mainly included descriptive statistics with categorical and continuous variables.

Results: Total 81 cases of duodenal polyps were studied in the period of 10 years. The median age was 48 years. Male: female ratio was 2.2:1. The most common presenting system was abdominal pain. We experienced both solitary and multiple polyps. Majority of the duodenal polyps were non-neoplastic, with unremarkable mucosa or inflammatory type.  Unlike previous studies the most common site for the hyperplastic polyp in the present study was the first part of the duodenum. Among the neoplastic polyps, adenomatous polyp was the most common type. Contrary to the previous studies, our study showed the first part of the duodenum as the most common site for the sporadic nonampullary adenomatous duodenal polyps. Of the rare entities, we encountered a single case each of lipomatous polyp and gangliocytic paraganglioma. Among the syndromes we encountered two cases of Peutz-Jeghers syndrome and one case of familial adenomatous polyp in our study population.

Conclusion: Duodenal polyps are rare finding on endoscopic examinations, though most of them are non-neoplastic in nature, vigilant examination under the microcope is required to rule out any neoplastic pathology and identify the risk of malignancy.

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