Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
DISCOVERIES (ISSN 2359-7232), 2022, January-March issue
Submitted: Feb. 17, 2022; Revised: Feb. 23, 2022; Accepted: Feb. 25, 2022; Published: March 01, 2022
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Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
Bhanu P. Jena (1,2,3,4,*), Lars Larsson (4,5), Domenico L. Gatti (4,6), Ionita Ghiran (4,7), Won Jin Cho (4)
(1) Department of Physiology, School of Medicine, Wayne State University, Detroit, MI, USA
(2) NanoBioScience Institute, Wayne State University, Detroit, MI, USA
(3) Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI, USA
(4) Viron Molecular Medicine Institute, Boston, MA, USA
(5) Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden
(6) Biochemistry, Microbiology and Immunology, School of Medicine, Wayne State University, Detroit, MI, USA
(7) Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
*Corresponding authors: Bhanu P. Jena, Ph.D., D.Sc., (dr. h.c. mult.), George E. Palade University Professor and Distinguished Professor, Wayne State University School of Medicine, President and Director, Viron "Molecular Medicine Institute" (MMI), One Boston Place, 26th Floor; Boston, MA 02108, USA; Office: 248-885-3640; E-mails: jenabp88@gmail.com; bjena@med.wayne.edu; Jena laboratory: jenalaboratory.com; vironinstitute.com
Disclosure: Corresponding author, Prof. Bhanu P. Jena, is a Senior Editor of the journal Discoveries. This article had 2 Editors assigned, namely Professor Elisa A. Liehn (Denmark) and Dr. Mircea Leabu (Romania).
Abstract
Metabolism and movement, among the critical determinants in the survival and success of an organism, are tightly regulated by the brain and skeletal muscle. At the cellular level, mitochondria -that powers life, and myosin - the molecular motor of the cell, have both evolved to serve this purpose. Although independently, the skeletal muscle and brain have been intensively investigated for over a century, their coordinated involvement in metabolism and movement remains poorly understood. Therefore, a fundamental understanding of the coordinated involvement of the brain and skeletal muscle in metabolism and movement holds great promise in providing a window to a wide range of life processes and in the development of tools and approaches in disease detection and therapy. Recent developments in new tools, technologies and approaches, and advances in computing power and machine learning, provides for the first time the opportunity to establish a new field of study, the ‘Science and Engineering of Metabolism and Movement’. This new field of study could provide substantial new insights and breakthrough into how metabolism and movement is governed at the systems level in an organism. The design and approach to accomplish this objective is briefly discussed in this article.
Access full text of the manuscript here: Full text (pdf)
References
1. Cha DS, Kaidanovich-Beilin O, McIntyre RS. Metabolism and the brain. The Scientist. 2021. Accessed from https://www.the-scientist.com/features/metabolism-and-the-brain-40103 in February 2022.
2. Amann M, Dempsey JA. Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance. J. Physiol. 2008; 586: 161–173.
3. Delezie J, Handschin C. Endocrine crosstalk between skeletal muscle and the brain. Front Neurol. 2018;9:698–5108.
4. Reyes A et.al. Actin and myosin contribute to mammalian mitochondria maintenance. Nucleic Acid Res. 2011;39:5098–5108.
5. Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73:1907–1920.
6. Benjamins JA, Nedelkoska L, Touil H, Stemmer, Carruthers NJ, Jena BP, Naik AR, Bar-Or A, Lisak RP. Exosome- enriched fractions from multiple sclerosis B cells induce oligodendrocyte death. Neurology: J Neuroimmunology and Neuroinflammation 2019;(6)3.
7. Naik AR, Pernal S, Lewis KT, Wu Y, Wu H, Carruthers NJ, Stemmer PM, Jena BP. Human skeletal muscle cells on engineered 3D platform express key growth and developmental proteins. ACS Biomaterials Science and Engineering. 2019;11;5(2):970-976.
8. Jena BP, Gatti DL, Arslanturk S, Pernal S, Taatjes DJ. Human Skeletal Muscle Cell Atlas: Unraveling Cellular Secrets Utilizing ‘Muscle-on-a-Chip’, Differential Expansion Microscopy, Mass Spectrometry, Nanothermometry and Machine Learning. Micron. 2018.
9. Chen F, Tillberg PW, Boyden ES. Expansion microscopy. Science. 2015;1260088.
10. Tillberg PW, Chen F, Piatkevich KD, Zhao Y, Yu C-C, English BP et al. Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies. Nature Biotechnology. 2016;34:987–992.
11. Zhao Y, Bucur O, Irshad H, Chen F, Weins A, Stancu AL et al. Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy. Nature Biotechnology. 2017;35: 957–964.
12. Bucur O, Fu F, Calderon M et al. Nanoscale imaging of clinical specimens using conventional and rapid-expansion pathology. Nature Protocols. 2020;15(5):1649-1672.
13. Lee CM, Tian X, Tsao C, Chen P, Huang TN, Hsueh YP, Chen BC. Macro photography with Lighsheet Illumination Enables Whole Expanded Brain Imaging with Single-cell Resolution. Discoveries 2021; 9(3): e133.
14. Pernal SP, Liyanaarachchi A, Gatti DL, Formosa B, Pulvender R, Kuhn ER, Ramos R, Naik AR, George K, Arslanturk S, Taatjes DJ, Jena BP. Nanoscale imaging using differential expansion microscopy. Histochem Cell Biol. 2020; 2020153: 469–480.
15. Trappe S, Costill D, Gallagher P, Creer A, Peters JR, Evans H, Riley DA, Fitts RH. Exercise in space: human skeletal muscle after 6 months aboard the International Space Station. J. Appl. Physiol. 2009;106:1159-1168.
16. Liu Y, Schlumberger A, Wirth K, Schmidtbleicher D, Steinacker JM. Different effects on human skeletal myosin heavy chain isoform expression: strength vs. combination training. J. Appl. Physiol. 2003;94: 2282-2288.
17. Fitts RH, Riley DR, Widrick JJ. Functional and structural adaptations of skeletal muscle to microgravity. J. Exp. Biol. 2001;204: 3201–3208.
18. Fitts RH, Riley DR, Widrick JJ. Physiology of a microgravity environment invited review: microgravity and skeletal muscle. J. Appl. Physiol. 2000;89: 823-839.
19. Laha SS, Naik AR, Kuhn ER, Alvarez M, Sujkowsky A, Wessells RJ, Jena BP. Nano thermometry measure of muscle efficiency. ACS Nano Lett. 2017;17(2): 1262-1268.
20. Bodine SC. Disuse-induced muscle wasting. International Journal of Biochemistry and Cell Biology 2013; 45: 2200-2208.
21. Llano-Diez M, Renaud G, Andersson M, Marrero HG, Cacciani N, Engquist H, Corpeno R, Artemenko K, Bergquist J, Larsson L. Mechanism underlying ICU muscle wasting and effects of passive mechanical loading. Critical Care 2012; 16: R209.
22. Llano-Diez M, Gustafson AM, Olsson C, Goransson H, Larsson L. Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model. BMC Genomics 2011; 12: 602.
23. Norman H, Nordquist J, Andersson P, Ansved T, Tang X, Dworkin B, Larsson L. Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression. Pflugers Archiv. 2006; 453: 53-66.
24. Piazza N, Gosangi B, Devilla S, Arking R, Wessells R. Exercise-training in young Drosophila melanogaster reduces age-related decline in mobility and cardiac performance. PLoS ONE 2009; 4: e5886.
25. Sujkowski A, Bazzell B, Carpenter K, Arking R, Wessells R. Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms. Aging. 2015; 7: 535-550.
26. Tinkerhess MJ, Healy L, Morgan M, Sujkowski A, Matthys E, Zheng L, Wessells RJ. The Drosophila PGC-1α Homolog spargel Modulates the Physiological Effects of Endurance Exercise. PLOS ONE 2012; 7: e31633.
27. Kovari LC, Brunzelle JS, Lewis KT, Cho WJ, Lee J-S, Taatjes DJ, Jena BP. X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release. Micron 2014; 56:37-43.
28. Saalfeld S, Fetter RD, Bock DD, A complete electron microscopy volume of the brain of adult Drosophila melanogaster. Cell. 2018 Jul 26;174(3):730-743.e22.
29. Cao G, Platisa J, Pieribone, VA, Raccugila D, Kunst M, Nitabach MN. Genetically targeted optical electrophysiology in intact neural circuits. Cell. 2013;154(4):904-13.
30. Stump CS, Henriksen EJ, Wei Y, Sowers JR. The metabolic syndrome: role of skeletal muscle metabolism. Ann. Med. 2006; 38: 389–402.
31. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. BMC Syst. Biol. 2011;5:180.
32. Bordbar A, Monk JM, King ZA, Palsson BO. Constraint based models predict metabolic and associated cellular functions. Nat. Rev. Genet. 2014;15: 107–120.
33. Mardinoglu A, Gatto F, Nielsen J. Genome-scale modeling of human metabolism - a systems biology approach. Biotechnol. J. 2013;8: 985–996.
34. Agren R, Bordel S, Mardinoglu A, Pornputtapong N, Nookaew I, Nielsen J. Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT. PLoS Comput. Biol. 2012;8: e1002518.
35. Fouladiha H, Marashi SA. Biomedical applications of cell- and tissue-specific metabolic network models. Journal of Biomedical Informatics. 2017;68:35–49.
36. Varemo L, Scheele C, Broholm C, Mardinoglu A, Kampf C, Asplund A et al. Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes, Cell Reports 2015;11: 921–933.
37. Orth, JD, Thiele I, Palsson BØ. "What is flux balance analysis?". Nature Biotechnology. 2010; 28(3): 245–248.
38. Lewis NE, Nagarajan H, Palsson BO. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nat Rev Microbiol. 2012;10(4):291-305.
39. Sierksma G, Zwols Y. Linear and Integer Optimization: Theory and Practice, Third Edition. CRC, 2015.
40. Lewis NE, Schramm G, Bordbar A, Schellenberger J, Andersen MP, Cheng JK et al., Large-scale in silico modeling of metabolic interactions between cell types in the human brain, Nat. Biotechnol. 2010; 28:1279–1285.
41. Çakir T, Alsan S, Saybasili H, Akin A, Ülgen KÖ. Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia, Theor. Biol. Med. Modell. 2007;4; 48.
42. Occhipinti R, Puchowicz MA, LaManna JC, Somersalo E, Calvetti D. Statistical analysis of metabolic pathways of brain metabolism at steady state, Ann. Biomed. Eng. 2007;35: 886–902.
43. Sertbas M, Ülgen K, Çakır T. Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network, FEBS Open Bio. 2014;4: 542–553.
44. Hämäläinen M, Hari R, Ilmoniemi RJ, Knuutila J, Lounasmaa OV. "Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain" Reviews of Modern Physics. 1993;65(2): 413–497.
45. Viron Molecular Medicine Institute (2021) https://www.vironinstitute.com
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