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Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement

DISCOVERIES (ISSN 2359-7232), 2022, January-March issue


Jena BP, Larsson L, Gatti DL, Ghiran I, Cho WJ. Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement. Discoveries 2022, 10(1): e144. DOI: 10.15190/d.2022.3

Submitted: Feb. 17, 2022; Revised: Feb. 23, 2022; Accepted: Feb. 25, 2022; Published: March 01, 2022

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Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement

Bhanu P. Jena (1,2,3,4,*), Lars Larsson (4,5), Domenico L. Gatti (4,6), Ionita Ghiran (4,7), Won Jin Cho (4)

(1) Department of Physiology, School of Medicine, Wayne State University, Detroit, MI, USA

(2) NanoBioScience Institute, Wayne State University, Detroit, MI, USA

(3) Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI, USA

(4) Viron Molecular Medicine Institute, Boston, MA, USA

(5) Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden

(6) Biochemistry, Microbiology and Immunology, School of Medicine, Wayne State University, Detroit, MI, USA

(7) Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

*Corresponding authors: Bhanu P. Jena, Ph.D., D.Sc., (dr. h.c. mult.), George E. Palade University Professor and Distinguished Professor, Wayne State University School of Medicine, President and Director, Viron "Molecular Medicine Institute" (MMI), One Boston Place, 26th Floor; Boston, MA 02108, USA; Office: 248-885-3640; E-mails: jenabp88@gmail.com; bjena@med.wayne.edu; Jena laboratory: jenalaboratory.com; vironinstitute.com

Disclosure: Corresponding author, Prof. Bhanu P. Jena, is a Senior Editor of the journal Discoveries. This article had 2 Editors assigned, namely Professor Elisa A. Liehn (Denmark) and Dr. Mircea Leabu (Romania).


Metabolism and movement, among the critical determinants in the survival and success of an organism, are tightly regulated by the brain and skeletal muscle. At the cellular level, mitochondria -that powers life, and myosin - the molecular motor of the cell, have both evolved to serve this purpose. Although independently, the skeletal muscle and brain have been intensively investigated for over a century, their coordinated involvement in metabolism and movement remains poorly understood. Therefore, a fundamental understanding of the coordinated involvement of the brain and skeletal muscle in metabolism and movement holds great promise in providing a window to a wide range of life processes and in the development of tools and approaches in disease detection and therapy. Recent developments in new tools, technologies and approaches, and advances in computing power and machine learning, provides for the first time the opportunity to establish a new field of study, the ‘Science and Engineering of Metabolism and Movement’. This new field of study could provide substantial new insights and breakthrough into how metabolism and movement is governed at the systems level in an organism. The design and approach to accomplish this objective is briefly discussed in this article.

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