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Discoveries Interview:
Prof. Jack Lawler on the discovery and significance of thrombospondins

DISCOVERIES (ISSN 2359-7232),2014, January-March

CITATION:

Discoveries Interview: Prof. Jack Lawler on the discovery and significance of thrombospondins. Discoveries 2014, Jan-Mar; 2(1): e12. DOI: 10.15190/d.2014.4;

Submitted: March 16, 2014; Published after revision:March 18, 2014

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Discoveries Interview: Prof. Jack Lawler on the discovery and significance of thrombospondins.


Jack Lawler Ph.D. is Professor of Pathology at Harvard Medical School and Director of Experimental Pathology at the Beth Israel Deaconess Medical Center, Boston, Mass. Additionally, Dr. Lawler is Co-Director of the Training Grant in Angiogenesis and Inflammation in the Department of Pathology at the Beth Israel Deaconess Medical Center and is the Leader of the Angiogenesis, Invasion and Metastasis Discipline-based Working Group of the Dana Farber/Harvard Cancer Center.

Dr. Lawler received his B.S. in Physics from Villanova University in 1971 and his Ph.D. in Physics from Boston College in 1976. He was a post-doctoral fellow at the Dana Farber Cancer Institute in the Structural Biology Laboratory where he performed the first purification and biochemical characterization of thrombospondin-1. In 1982, Dr. Lawler became Assistant Professor in the Department of Medicine at Tufts University Medical School and St. Elizabeth’s Hospital, Boston. While Dr. Lawler was a Visiting Scientist in Richard Hynes’ lab at MIT, he cloned and sequenced thrombospondin-1 and engineered the thrombospondin-1-null mouse. In 1988, Dr. Lawler became Associate Professor of Pathology at Harvard Medical School and Brigham and Women’s Hospital. He has published over 200 articles and co-authored the book “The Thrombospondin Gene Family”. Dr. Lawler has also served on the editorial boards of the Journal of Cellular and Molecular Medicine, Current Drug Targets, Journal of Cell Communication and Signaling, and Discoveries. The NIH has continuously supported his work for three decades.

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References

1.Resovi A, Pinessi D, Chiorino G and Taraboletti G. Current understanding of the thrombospondin-1 interactome. Matrix Biol. 2014; in press.
2.Lawler J. Thrombospondin 1. UCSD Nature Molecule Pages 2010. doi: 10.1038/mp.a002276.01.
3.Lawler JW, Slayter HS and Coligan JE. Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem. 1978; 253:8609-8616.
4.Schultz-Cherry S and Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol. 1993; 122:923-932.
5.Lawler J and Hynes RO. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol. 1986; 103:1635-1648.
6.Dameron KM, Volpert OV, Tainsky MA and Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994;265:1582-1584.

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